Seroatlas · Human Serome Atlas

MAP1LC3B

Microtubule-associated protein 1 light chain 3 beta

Also known as: ATG8F, MLP3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZQ8
Gene: MAP1LC3B
Ensembl: ENSG00000140941
Chromosome: 16
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Centriolar satellite

OverviewNCBI Gene

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9GZQ8|MAP1LC3B
     1  MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM
    61  SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SEKDEDGFLY MVYASQETFG
   121  MKLSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1LC3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 238 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 238 nTPM
bone marrow: 232 nTPM
cerebellum: 171 nTPM
tongue: 165 nTPM
midbrain: 151 nTPM
spinal cord: 141 nTPM

Single-cell type

neutrophils: 1,134 nCPM
esophageal apical cells: 929 nCPM
syncytiotrophoblasts: 849 nCPM
endometrial glandular cells: 611 nCPM
pancreatic duct cells: 524 nCPM
platelets: 460 nCPM

Immune cell

basophil: 313 nTPM
neutrophil: 215 nTPM
eosinophil: 199 nTPM
total PBMC: 109 nTPM
T-reg: 108 nTPM
NK-cell: 105 nTPM

Brain region

pons: 172 nTPM
midbrain: 154 nTPM
medulla oblongata: 150 nTPM
hypothalamus: 147 nTPM
thalamus: 138 nTPM
cerebral cortex: 136 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP1LC3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP1LC3B as an antibody target. Whether an autoantibody or antibody against MAP1LC3B could matter depends on whether native MAP1LC3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP1LC3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP1LC3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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