MAP1B

Protein identityUniProt · HPA

UniProt accession

P46821

Gene

MAP1B

Ensembl

ENSG00000131711

Chromosome

5

Canonical length

2468 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol,Equatorial segment

OverviewNCBI Gene

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

2468 residues, UniProt reviewed canonical sequence.

>P46821|MAP1B
     1  MATVVVEATE PEPSGSIANP AASTSPSLSH RFLDSKFYLL VVVGEIVTEE HLRRAIGNIE
    61  LGIRSWDTNL IECNLDQELK LFVSRHSARF SPEVPGQKIL HHRSDVLETV VLINPSDEAV
   121  STEVRLMITD AARHKLLVLT GQCFENTGEL ILQSGSFSFQ NFIEIFTDQE IGELLSTTHP
   181  ANKASLTLFC PEEGDWKNSN LDRHNLQDFI NIKLNSASIL PEMEGLSEFT EYLSESVEVP
   241  SPFDILEPPT SGGFLKLSKP CCYIFPGGRG DSALFAVNGF NMLINGGSER KSCFWKLIRH
   301  LDRVDSILLT HIGDDNLPGI NSMLQRKIAE LEEEQSQGST TNSDWMKNLI SPDLGVVFLN
   361  VPENLKNPEP NIKMKRSIEE ACFTLQYLNK LSMKPEPLFR SVGNTIDPVI LFQKMGVGKL
   421  EMYVLNPVKS SKEMQYFMQQ WTGTNKDKAE FILPNGQEVD LPISYLTSVS SLIVWHPANP
   481  AEKIIRVLFP GNSTQYNILE GLEKLKHLDF LKQPLATQKD LTGQVPTPVV KQTKLKQRAD
   541  SRESLKPAAK PLPSKSVRKE SKEETPEVTK VNHVEKPPKV ESKEKVMVKK DKPIKTETKP
   601  SVTEKEVPSK EEPSPVKAEV AEKQATDVKP KAAKEKTVKK ETKVKPEDKK EEKEKPKKEV
   661  AKKEDKTPIK KEEKPKKEEV KKEVKKEIKK EEKKEPKKEV KKETPPKEVK KEVKKEEKKE
   721  VKKEEKEPKK EIKKLPKDAK KSSTPLSEAK KPAALKPKVP KKEESVKKDS VAAGKPKEKG
   781  KIKVIKKEGK AAEAVAAAVG TGATTAAVMA AAGIAAIGPA KELEAERSLM SSPEDLTKDF
   841  EELKAEEVDV TKDIKPQLEL IEDEEKLKET EPVEAYVIQK EREVTKGPAE SPDEGITTTE
   901  GEGECEQTPE ELEPVEKQGV DDIEKFEDEG AGFEESSETG DYEEKAETEE AEEPEEDGEE
   961  HVCVSASKHS PTEDEESAKA EADAYIREKR ESVASGDDRA EEDMDEAIEK GEAEQSEEEA
  1021  DEEDKAEDAR EEEYEPEKME AEDYVMAVVD KAAEAGGAEE QYGFLTTPTK QLGAQSPGRE
  1081  PASSIHDETL PGGSESEATA SDEENREDQP EEFTATSGYT QSTIEISSEP TPMDEMSTPR
  1141  DVMSDETNNE ETESPSQEFV NITKYESSLY SQEYSKPADV TPLNGFSEGS KTDATDGKDY
  1201  NASASTISPP SSMEEDKFSR SALRDAYCSE VKASTTLDIK DSISAVSSEK VSPSKSPSLS
  1261  PSPPSPLEKT PLGERSVNFS LTPNEIKVSA EAEVAPVSPE VTQEVVEEHC ASPEDKTLEV
  1321  VSPSQSVTGS AGHTPYYQSP TDEKSSHLPT EVIEKPPAVP VSFEFSDAKD ENERASVSPM
  1381  DEPVPDSESP IEKVLSPLRS PPLIGSESAY ESFLSADDKA SGRGAESPFE EKSGKQGSPD
  1441  QVSPVSEMTS TSLYQDKQEG KSTDFAPIKE DFGQEKKTDD VEAMSSQPAL ALDERKLGDV
  1501  SPTQIDVSQF GSFKEDTKMS ISEGTVSDKS ATPVDEGVAE DTYSHMEGVA SVSTASVATS
  1561  SFPEPTTDDV SPSLHAEVGS PHSTEVDDSL SVSVVQTPTT FQETEMSPSK EECPRPMSIS
  1621  PPDFSPKTAK SRTPVQDHRS EQSSMSIEFG QESPEQSLAM DFSRQSPDHP TVGAGVLHIT
  1681  ENGPTEVDYS PSDMQDSSLS HKIPPMEEPS YTQDNDLSEL ISVSQVEASP STSSAHTPSQ
  1741  IASPLQEDTL SDVAPPRDMS LYASLTSEKV QSLEGEKLSP KSDISPLTPR ESSPLYSPTF
  1801  SDSTSAVKEK TATCHSSSSP PIDAASAEPY GFRASVLFDT MQHHLALNRD LSTPGLEKDS
  1861  GGKTPGDFSY AYQKPEETTR SPDEEDYDYE SYEKTTRTSD VGGYYYEKIE RTTKSPSDSG
  1921  YSYETIGKTT KTPEDGDYSY EIIEKTTRTP EEGGYSYDIS EKTTSPPEVS GYSYEKTERS
  1981  RRLLDDISNG YDDSEDGGHT LGDPSYSYET TEKITSFPES EGYSYETSTK TTRTPDTSTY
  2041  CYETAEKITR TPQASTYSYE TSDLCYTAEK KSPSEARQDV DLCLVSSCEY KHPKTELSPS
  2101  FINPNPLEWF ASEEPTEESE KPLTQSGGAP PPPGGKQQGR QCDETPPTSV SESAPSQTDS
  2161  DVPPETEECP SITADANIDS EDESETIPTD KTVTYKHMDP PPAPVQDRSP SPRHPDVSMV
  2221  DPEALAIEQN LGKALKKDLK EKTKTKKPGT KTKSSSPVKK SDGKSKPLAA SPKPAGLKES
  2281  SDKVSRVASP KKKESVEKAA KPTTTPEVKA ARGEEKDKET KNAANASASK SAKTATAGPG
  2341  TTKTTKSSAV PPGLPVYLDL CYIPNHSNSK NVDVEFFKRV RSSYYVVSGN DPAAEEPSRA
  2401  VLDALLEGKA QWGSNMQVTL IPTHDSEVMR EWYQETHEKQ QDLNIMVLAS SSTVVMQDES
  2461  FPACKIEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

144 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP1B.

Disease | AllUniProt

Conditions MAP1B is implicated in, by any mechanism.

• Periventricular nodular heterotopia 9 (PVNH9) MIM:618918
• Deafness, autosomal dominant, 83 (DFNA83) MIM:619808

Disease | GeneticClinVar

43 pathogenic / likely-pathogenic of 651 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Periventricular nodular heterotopia 9
• Periventricular nodular heterotopia
• MAP1B-related disorder
• White matter deficit
• Hypoplasia of the corpus callosum

ReferencesPubMed · IEDB

Publications for MAP1B from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.13

gnomAD pLI

1

gnomAD missense Z

2.51

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon extension
• axonogenesis
• cellular response to growth factor stimulus
• cellular response to peptide hormone stimulus
• dendrite development
• establishment of monopolar cell polarity
• microtubule bundle formation
• microtubule cytoskeleton organization
• mitochondrion transport along microtubule
• negative regulation of intracellular transport
• negative regulation of microtubule depolymerization
• neuron migration
• neuron projection development
• odontoblast differentiation
• peripheral nervous system axon regeneration
• positive regulation of axon extension
• positive regulation of microtubule polymerization
• positive regulation of neuron differentiation
• regulation of microtubule depolymerization
• regulation of postsynapse assembly
• response to carbohydrate
• response to estradiol
• response to insecticide
• response to mechanical stimulus
• response to vitamin A
• response to xenobiotic stimulus
• synapse assembly
• developmental maturation
• induction of synaptic plasticity by chemical substance

Molecular functions

• actin binding
• microtubule binding
• phospholipid binding
• protein-containing complex binding
• structural molecule activity

Cellular components

• apical dendrite
• axon
• basal dendrite
• cytosol
• dendrite
• dendritic spine
• glutamatergic synapse
• growth cone
• hippocampal mossy fiber
• microtubule
• microtubule associated complex
• neuronal cell body
• perikaryon
• perinuclear region of cytoplasm
• photoreceptor outer segment
• plasma membrane
• postsynaptic density
• somatodendritic compartment
• synapse
• varicosity

Protein domainsUniProt · Pfam · InterPro

• Microtubule associated protein 1
• Microtubule-associated protein 1B/S, N-terminal domain
• Microtubule-associated protein 1A/B/S-like, MBL-like domain
• Microtubule-associated protein 1B N-terminal
• MAP1B MBL-like domain
• Neuraxin/MAP1B repeat
• Neuraxin and MAP1B repeat

KeywordsUniProt

• Acetylation
• Cell projection
• Cytoplasm
• Cytoskeleton
• Deafness
• Microtubule
• Non-syndromic deafness
• Phosphoprotein
• Repeat
• S-nitrosylation
• Synapse

InteractionsUniProt · HPA

Protein binding partners of MAP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANP32A
• ELAVL2
• ELAVL3
• KIRREL3
• MAP1LC3B
• TIAM2
• TMEM185A
• DAPK1
• HTR6
• KRT18
• STK4