Seroatlas · Human Serome Atlas

JMY

Junction-mediating and -regulatory protein

Also known as: FLJ37870, JMY_HUMAN, WHAMM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9B5
Gene: JMY
Ensembl: ENSG00000152409
Chromosome: 5
Canonical length: 988 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables microtubule binding activity. Involved in cellular response to starvation. Located in autophagosome membrane; cell leading edge; and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

988 residues, UniProt reviewed canonical sequence.

>Q8N9B5|JMY
     1  MSFALEETLE SDWVAVRPHV FDEREKHKFV FIVAWNEIEG KFAITCHNRT AQRQRSGSRE
    61  QAGARGGAEA GGAASDGSRG PGSPAGRGRP EATASATLVR SPGPRRSSAW AEGGSPRSTR
   121  SLLGDPRLRS PGSKGAESRL RSPVRAKPIP GQKTSEADDA AGAAAAAARP APREAQVSSV
   181  RIVSASGTVS EEIEVLEMVK EDEAPLALSD AEQPPPATEL ESPAEECSWA GLFSFQDLRA
   241  VHQQLCSVNS QLEPCLPVFP EEPSGMWTVL FGGAPEMTEQ EIDTLCYQLQ VYLGHGLDTC
   301  GWKILSQVLF TETDDPEEYY ESLSELRQKG YEEVLQRARK RIQELLDKHK NTESMVELLD
   361  LYQMEDEAYS SLAEATTELY QYLLQPFRDM RELAMLRRQQ IKISMENDYL GPRRIESLQK
   421  EDADWQRKAH MAVLSIQDLT VKYFEITAKA QKAVYDRMRA DQKKFGKASW AAAAERMEKL
   481  QYAVSKETLQ MMRAKEICLE QRKHALKEEM QSLRGGTEAI ARLDQLEADY YDLQLQLYEV
   541  QFEILKCEEL LLTAQLESIK RLISEKRDEV VYYDTYESME AMLEKEEMAA SAYLQREELQ
   601  KLQQKARQLE ARRGRVSAKK SYLRNKKEIC IAKHNEKIQQ RTRIEDEYRT HHTVQLKREK
   661  LHDEEERKSA WVSQERQRTL DRLRTFKQRY PGQVILKSTR LRLAHARRKG AASPVLQEDH
   721  CDSLPSVLQV EEKTEEVGEG RVKRGPSQTT EPQSLVQLED TSLTQLEATS LPLSGVTSEL
   781  PPTISLPLLN NNLEPCSVTI NPLPSPLPPT PPPPPPPPPP PPPPPLPVAK DSGPETLEKD
   841  LPRKEGNEKR IPKSASAPSA HLFDSSQLVS ARKKLRKTAE GLQRRRVSSP MDEVLASLKR
   901  GSFHLKKVEQ RTLPPFPDED DSNNILAQIR KGVKLKKVQK DVLRESFTLL PDTDPLTRSI
   961  HEALRRIKEA SPESEDEEEA LPCTDWEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JMY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

ovary: 13 nTPM
endometrium: 11 nTPM
retina: 11 nTPM
parathyroid gland: 11 nTPM
colon: 10 nTPM
bone marrow: 9.7 nTPM

Single-cell type

innate lymphoid cells: 698 nCPM
plasma cells: 250 nCPM
t-cells: 228 nCPM
tuft cells: 219 nCPM
monocytes: 174 nCPM
pdcs: 167 nCPM

Immune cell

NK-cell: 0.9 nTPM
naive CD4 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 23 nTPM
white matter: 23 nTPM
basal ganglia: 22 nTPM
thalamus: 22 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.96
gnomAD missense Z: 1.71
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JMY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JMY as an antibody target. Whether an autoantibody or antibody against JMY could matter depends on whether native JMY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JMY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JMY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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