Seroatlas · Human Serome Atlas

MOAP1

Modulator of apoptosis 1

Also known as: MAP-1, MOAP1_HUMAN, PNMA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BY2
Gene
MOAP1
Ensembl
ENSG00000165943
Chromosome
14
Canonical length
351 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q96BY2|MOAP1
     1  MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR LLGRMFRRDE
    61  NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN TFLSRLNEFL AGEGMTVGEL
   121  SRALGHENGS LDPEQGMIPE MWAPMLAQAL EALQPALQCL KYKKLRVFSG RESPEPGEEE
   181  FGRWMFHTTQ MIKAWQVPDV EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV
   241  FGVTDNPREL QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA
   301  GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 132 nTPM
  • hypothalamus: 94 nTPM
  • retina: 85 nTPM
  • cerebellum: 82 nTPM
  • basal ganglia: 74 nTPM
  • hippocampal formation: 61 nTPM

Single-cell type

  • other brain neurons: 74 nCPM
  • brain inhibitory neurons: 43 nCPM
  • brain excitatory neurons: 40 nCPM
  • bergmann glia: 19 nCPM
  • oligodendrocytes: 15 nCPM
  • oligodendrocyte progenitor cells: 11 nCPM

Immune cell

  • basophil: 54 nTPM
  • naive CD4 T-cell: 23 nTPM
  • naive CD8 T-cell: 21 nTPM
  • MAIT T-cell: 20 nTPM
  • eosinophil: 20 nTPM
  • memory CD8 T-cell: 19 nTPM

Brain region

  • hypothalamus: 136 nTPM
  • cerebral cortex: 122 nTPM
  • pons: 92 nTPM
  • basal ganglia: 90 nTPM
  • white matter: 87 nTPM
  • hippocampal formation: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOAP1 as an antibody target. Whether an autoantibody or antibody against MOAP1 could matter depends on whether native MOAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MOAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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