Seroatlas · Human Serome Atlas

PHB2

Prohibitin-2

Also known as: Bap37, BCAP37, p22, PHB2_HUMAN, REA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99623
Gene: PHB2
Ensembl: ENSG00000215021
Chromosome: 12
Canonical length: 299 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables amide binding activity; protein dimerization activity; and sphingolipid binding activity. Involved in several processes, including RIG-I signaling pathway; positive regulation of cell cycle phase transition; and regulation of DNA-templated transcription. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q99623|PHB2
     1  MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ
    61  DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ MVNISLRVLS RPNAQELPSM
   121  YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA SQLITQRAQV SLLIRRELTE RAKDFSLILD
   181  DVAITELSFS REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE
   241  ALSKNPGYIK LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 292 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 292 nTPM
liver: 258 nTPM
ovary: 241 nTPM
tongue: 216 nTPM
pancreas: 214 nTPM
esophagus: 180 nTPM

Single-cell type

esophageal basal cells: 396 nCPM
migrating cytotrophoblasts: 338 nCPM
extravillous trophoblasts: 310 nCPM
decidual stromal cells: 286 nCPM
enteric stem cells: 268 nCPM
enteric transient amplifying cells: 264 nCPM

Immune cell

myeloid DC: 139 nTPM
plasmacytoid DC: 129 nTPM
T-reg: 124 nTPM
NK-cell: 118 nTPM
total PBMC: 114 nTPM
intermediate monocyte: 107 nTPM

Brain region

choroid plexus: 52 nTPM
thalamus: 51 nTPM
cerebellum: 48 nTPM
white matter: 46 nTPM
spinal cord: 46 nTPM
amygdala: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.99
DepMap mean gene effect: -1.95
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHB2 as an antibody target. Whether an autoantibody or antibody against PHB2 could matter depends on whether native PHB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHB2 is annotated at the cell surface, where native PHB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PHB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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