Seroatlas · Human Serome Atlas

CEP131

Centrosomal protein of 131 kDa

Also known as: AZ1, AZI1, CP131_HUMAN, KIAA1118

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPN4
Gene
CEP131
Ensembl
ENSG00000141577
Chromosome
17
Canonical length
1083 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Primary cilium,Centriolar satellite,Basal body,Flagellar centriole

OverviewNCBI Gene

Enables protein homodimerization activity. Involved in several processes, including intraciliary transport involved in cilium assembly; protein localization to centrosome; and regulation of centrosome duplication. Located in several cellular components, including ciliary transition zone; intercellular bridge; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q9UPN4|CEP131
     1  MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT GSEQKRKVLE
    61  ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM LFEGSPSGKK RPASLSTAPS
   121  EKGATWNVLD DQPRGFTLPS NARSSSALDS PAGPRRKECT VALAPNFTAN NRSNKGAVGN
   181  CVTTMVHNRY TPSERAPPLK SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA
   241  RNNTGGSTGL PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK
   301  REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR AQKASTAERG
   361  PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG LPAAGPGDRC LPTSDSSPEP
   421  QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH
   481  HRGRYAWASE VTTEDDASSL TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME
   541  KSGQDQLDSQ QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL
   601  TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA VVAELKQEDQ
   661  RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT KKIKEVTVRG LEPEIQKLIA
   721  RHKQEVRRLK SLHEAELLQS DERASQRCLR QAEELREQLE REKEALGQQE RERARQRFQQ
   781  HLEQEQWALQ QQRQRLYSEV AEERERLGQQ AARQRAELEE LRQQLEESSS ALTRALRAEF
   841  EKGREEQERR HQMELNTLKQ QLELERQAWE AGRTRKEEAW LLNREQELRE EIRKGRDKEI
   901  ELVIHRLEAD MALAKEESEK AAESRIKRLR DKYEAELSEL EQSERKLQER CSELKGQLGE
   961  AEGENLRLQG LVRQKERALE DAQAVNEQLS SERSNLAQVI RQEFEDRLAA SEEETRQAKA
  1021  ELATLQARQQ LELEEVHRRV KTALARKEEA VSSLRTQHEA AVKRADHLEE LLEQHRRPTP
  1081  STK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP131 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • spleen: 19 nTPM
  • cerebellum: 18 nTPM
  • heart muscle: 16 nTPM
  • pituitary gland: 16 nTPM
  • cervix: 14 nTPM

Single-cell type

  • undifferentiated spermatogonia: 34 nCPM
  • late spermatids: 29 nCPM
  • late primary spermatocytes: 26 nCPM
  • respiratory ciliated cells: 22 nCPM
  • respiratory ionocytes: 20 nCPM
  • differentiating spermatogonia: 19 nCPM

Immune cell

  • non-classical monocyte: 4.7 nTPM
  • memory B-cell: 3 nTPM
  • intermediate monocyte: 2.3 nTPM
  • basophil: 2.1 nTPM
  • plasmacytoid DC: 2 nTPM
  • myeloid DC: 1.8 nTPM

Brain region

  • cerebellum: 11 nTPM
  • choroid plexus: 11 nTPM
  • cerebral cortex: 9.5 nTPM
  • medulla oblongata: 9.2 nTPM
  • white matter: 9 nTPM
  • amygdala: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centrosomal protein of 131kDa

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP131 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP131 as an antibody target. Whether an autoantibody or antibody against CEP131 could matter depends on whether native CEP131 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP131 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP131 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP131. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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