Seroatlas · Human Serome Atlas

FYB1

FYN-binding protein 1

Also known as: ADAP, FYB, FYB-120/130, FYB1_HUMAN, SLAP-130

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15117
Gene: FYB1
Ensembl: ENSG00000082074
Chromosome: 5
Canonical length: 783 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>O15117|FYB1
     1  MAKYNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSNVPKFGSP
    61  KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPASLTT RDPEAKVGFL KPVGPKPINL
   121  PKEDSKPTFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TSENEQKQAF PKLTGVKGKF
   181  MSASQDLEPK PLFPKPAFGQ KPPLSTENSH EDESPMKNVS SSKGSPAPLG VRSKSGPLKP
   241  AREDSENKDH AGEISSLPFP GVVLKPAASR GGPGLSKNGE EKKEDRKIDA AKNTFQSKIN
   301  QEELASGTPP ARFPKAPSKL TVGGPWGQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP
   361  NRPPNVDLTK FHKTSSGNST SKGQTSYSTT SLPPPPPSHP ASQPPLPASH PSQPPVPSLP
   421  PRNIKPPFDL KSPVNEDNQD GVTHSDGAGN LDEEQDSEGE TYEDIEASKE REKKREKEEK
   481  KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII
   541  RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE
   601  QDDISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGFPAP PKQLDMGDEV YDDVDTSDFP
   661  VSSAEMSQGT NVGKAKTEEK DLKKLKKQEK EEKDFRKKFK YDGEIRVLYS TKVTTSITSK
   721  KWGTRDLQVK PGESLEVIQT TDDTKVLCRN EEGKYGYVLR SYLADNDGEI YDDIADGCIY
   781  DND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FYB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

thymus: 105 nTPM
lymph node: 80 nTPM
appendix: 78 nTPM
spleen: 69 nTPM
tonsil: 59 nTPM
bone marrow: 50 nTPM

Single-cell type

neutrophils: 2,831 nCPM
tuft cells: 1,798 nCPM
neutrophil progenitors: 1,172 nCPM
microglia: 986 nCPM
platelets: 900 nCPM
kupffer cells: 865 nCPM

Immune cell

neutrophil: 1,680 nTPM
non-classical monocyte: 488 nTPM
intermediate monocyte: 407 nTPM
total PBMC: 401 nTPM
classical monocyte: 360 nTPM
eosinophil: 356 nTPM

Brain region

pons: 43 nTPM
medulla oblongata: 39 nTPM
white matter: 32 nTPM
thalamus: 31 nTPM
spinal cord: 23 nTPM
midbrain: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FYB1.

Disease | AllUniProt

Conditions FYB1 is implicated in, by any mechanism.

Thrombocytopenia 3 (THC3) MIM:273900

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 235 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Thrombocytopenia 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.24
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FYB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FYB1 as an antibody target. Whether an autoantibody or antibody against FYB1 could matter depends on whether native FYB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FYB1 is annotated at the cell surface, where native FYB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FYB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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