Seroatlas · Human Serome Atlas

CD79B

B-cell antigen receptor complex-associated protein beta chain

Also known as: B29, CD79B_HUMAN, Ig-beta, IGB, Igbeta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40259
Gene: CD79B
Ensembl: ENSG00000007312
Chromosome: 17
Canonical length: 229 aa
Protein class: Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>P40259|CD79B
     1  MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT
    61  VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY
   121  FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL
   181  LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD79B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 248 nTPM

Expression across tissuesHPA

Tissue

lymph node: 248 nTPM
tonsil: 191 nTPM
spleen: 143 nTPM
appendix: 66 nTPM
small intestine: 62 nTPM
bone marrow: 51 nTPM

Single-cell type

b-cells: 19 nCPM
plasma cells: 2.4 nCPM
hematopoietic stem cells: 1.5 nCPM
monocytes: 1.3 nCPM
nk-cells: 1.1 nCPM
somatotrophs: 0.9 nCPM

Immune cell

naive B-cell: 1,489 nTPM
memory B-cell: 1,119 nTPM
non-classical monocyte: 301 nTPM
intermediate monocyte: 189 nTPM
total PBMC: 110 nTPM
T-reg: 107 nTPM

Brain region

cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
amygdala: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD79B.

Disease | AllUniProt

Conditions CD79B is implicated in, by any mechanism.

Agammaglobulinemia 6, autosomal recessive (AGM6) MIM:612692

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 202 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Agammaglobulinemia 6, autosomal recessive
Malignant lymphoma, large B-cell, diffuse
Primary central nervous system lymphoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD79B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD79B as an antibody target. Whether an autoantibody or antibody against CD79B could matter depends on whether native CD79B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD79B is annotated at the cell surface, where native CD79B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD79B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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