Seroatlas · Human Serome Atlas

HCLS1

Hematopoietic lineage cell-specific protein

Also known as: CTTNL, HCLS1_HUMAN, HS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14317
Gene
HCLS1
Ensembl
ENSG00000180353
Chromosome
3
Canonical length
486 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein kinase binding activity; and signaling adaptor activity. Involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein import into nucleus. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>P14317|HCLS1
     1  MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
    61  VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF
   121  GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE
   181  TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA
   241  KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS
   301  EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY
   361  EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA
   421  GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN
   481  YVKLLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCLS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
291 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 291 nTPM
  • tonsil: 227 nTPM
  • lymph node: 194 nTPM
  • bone marrow: 145 nTPM
  • appendix: 139 nTPM
  • thymus: 131 nTPM

Single-cell type

  • neutrophils: 1,496 nCPM
  • kupffer cells: 1,302 nCPM
  • monocytes: 470 nCPM
  • neutrophil progenitors: 443 nCPM
  • macrophages: 412 nCPM
  • cdc: 294 nCPM

Immune cell

  • neutrophil: 1,624 nTPM
  • total PBMC: 1,426 nTPM
  • eosinophil: 1,183 nTPM
  • non-classical monocyte: 1,002 nTPM
  • intermediate monocyte: 870 nTPM
  • classical monocyte: 713 nTPM

Brain region

  • white matter: 27 nTPM
  • medulla oblongata: 24 nTPM
  • spinal cord: 18 nTPM
  • thalamus: 17 nTPM
  • pons: 17 nTPM
  • hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
-0.05
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HCLS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCLS1 as an antibody target. Whether an autoantibody or antibody against HCLS1 could matter depends on whether native HCLS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCLS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HCLS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HCLS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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