Seroatlas · Human Serome Atlas

SH2D1B

SH2 domain-containing protein 1B

Also known as: EAT2, SH21B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14796
Gene: SH2D1B
Ensembl: ENSG00000198574
Chromosome: 1
Canonical length: 132 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>O14796|SH2D1B
     1  MDLPYYHGRL TKQDCETLLL KEGVDGNFLL RDSESIPGVL CLCVSFKNIV YTYRIFREKH
    61  GYYRIQTAEG SPKQVFPSLK ELISKFEKPN QGMVVHLLKP IKRTSPSLRW RGLKLELETF
   121  VNSNSDYVDV LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 11 nTPM
spleen: 7.1 nTPM
tongue: 6.1 nTPM
bone marrow: 4.2 nTPM
lung: 2.1 nTPM
esophagus: 1.3 nTPM

Single-cell type

nk-cells: 167 nCPM
innate lymphoid cells: 43 nCPM
esophageal apical cells: 24 nCPM
myonuclei: 18 nCPM
epicardial cells: 9.1 nCPM
t-cells: 8.8 nCPM

Immune cell

NK-cell: 377 nTPM
non-classical monocyte: 150 nTPM
total PBMC: 67 nTPM
intermediate monocyte: 31 nTPM
myeloid DC: 6.8 nTPM
gdT-cell: 6.7 nTPM

Brain region

white matter: 2.4 nTPM
cerebral cortex: 2.2 nTPM
basal ganglia: 1.4 nTPM
hippocampal formation: 0.5 nTPM
midbrain: 0.4 nTPM
pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.01
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2D1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D1B as an antibody target. Whether an autoantibody or antibody against SH2D1B could matter depends on whether native SH2D1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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