Seroatlas · Human Serome Atlas

TEC

Tyrosine-protein kinase Tec

Also known as: PSCTK4, TEC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42680
Gene
TEC
Ensembl
ENSG00000135605
Chromosome
4
Canonical length
631 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>P42680|TEC
     1  MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK
    61  CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY
   121  HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS
   181  EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN
   241  NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY
   301  HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY
   361  EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL
   421  THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL
   481  ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS
   541  RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR
   601  CWQEKPEGRP SFEDLLRTID ELVECEETFG R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
5.8 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 5.8 nTPM
  • epididymis: 4 nTPM
  • esophagus: 3.4 nTPM
  • skin: 3.4 nTPM
  • tonsil: 3.1 nTPM
  • lymph node: 2.9 nTPM

Single-cell type

  • megakaryocyte progenitors: 354 nCPM
  • hematopoietic stem cells: 248 nCPM
  • esophageal apical cells: 173 nCPM
  • mast cells: 164 nCPM
  • megakaryocyte-erythroid progenitors: 164 nCPM
  • thymocytes: 160 nCPM

Immune cell

  • basophil: 21 nTPM
  • eosinophil: 13 nTPM
  • NK-cell: 3.6 nTPM
  • myeloid DC: 1.5 nTPM
  • memory B-cell: 1 nTPM
  • intermediate monocyte: 0.7 nTPM

Brain region

  • pons: 2.9 nTPM
  • choroid plexus: 2.8 nTPM
  • thalamus: 2.2 nTPM
  • medulla oblongata: 2.1 nTPM
  • cerebral cortex: 1.4 nTPM
  • hypothalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
1.6
DepMap mean gene effect
-0.05
DepMap dependency class
none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEC as an antibody target. Whether an autoantibody or antibody against TEC could matter depends on whether native TEC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEC is annotated at the cell surface, where native TEC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TEC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...