IL5

Protein identityUniProt · HPA

UniProt accession

P05113

Gene

IL5

Ensembl

ENSG00000113525

Chromosome

5

Canonical length

134 aa

Protein class

Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>P05113|IL5
     1  MRMLLHLSLL ALGAAYVYAI PTEIPTSALV KETLALLSTH RTLLIANETL RIPVPVHKNH
    61  QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG QKKKCGEERR RVNQFLDYLQ
   121  EFLGVMNTEW IIES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

4.8 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL5.

Disease | AutoantibodyPubMed

Conditions in which antibodies against IL5 are reported. Each links to that disease's full target list.

• Granulomatosis with Polyangiitis 8
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 5

Showing 2 of 3 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for IL5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.46

gnomAD pLI

0.01

gnomAD missense Z

-0.11

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• immune response
• inflammatory response
• interleukin-5-mediated signaling pathway
• positive regulation of B cell proliferation
• positive regulation of eosinophil differentiation
• positive regulation of immunoglobulin production
• positive regulation of podosome assembly
• positive regulation of receptor signaling pathway via JAK-STAT
• positive regulation of transcription by RNA polymerase II

Molecular functions

• cytokine activity
• growth factor activity
• interleukin-5 receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Four-helical cytokine-like, core
• Interleukin-5
• Interleukin 5

KeywordsUniProt

• Cytokine
• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSF2RB
• IL5RA
• LYN