MS4A2

Protein identityUniProt · HPA

UniProt accession

Q01362

Gene

MS4A2

Ensembl

ENSG00000149534

Chromosome

11

Canonical length

244 aa

Protein class

FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q01362|MS4A2
     1  MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF
    61  LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER
   121  RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE
   181  IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP
   241  PIDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.73

gnomAD pLI

0

gnomAD missense Z

-0.31

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• immune response

Molecular functions

• IgE binding

Cellular components

• external side of plasma membrane
• Fc-epsilon receptor I complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• CD20-like, transmembrane domain
• Membrane-spanning 4-domains subfamily A
• CD20-like family

KeywordsUniProt

• Disulfide bond
• IgE-binding protein
• Membrane
• Phosphoprotein
• Receptor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MS4A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGR
• LYN