Seroatlas · Human Serome Atlas

LPXN

Leupaxin

Also known as: LDPL, LPXN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60711
Gene
LPXN
Ensembl
ENSG00000110031
Chromosome
11
Canonical length
386 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Focal adhesion sites,Cytosol

OverviewNCBI Gene

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>O60711|LPXN
     1  MEELDALLEE LERSTLQDSD EYSNPAPLPL DQHSRKETNL DETSEILSIQ DNTSPLPAQL
    61  VYTTNIQELN VYSEAQEPKE SPPPSKTSAA AQLDELMAHL TEMQAKVAVR ADAGKKHLPD
   121  KQDHKASLDS MLGGLEQELQ DLGIATVPKG HCASCQKPIA GKVIHALGQS WHPEHFVCTH
   181  CKEEIGSSPF FERSGLAYCP NDYHQLFSPR CAYCAAPILD KVLTAMNQTW HPEHFFCSHC
   241  GEVFGAEGFH EKDKKPYCRK DFLAMFSPKC GGCNRPVLEN YLSAMDTVWH PECFVCGDCF
   301  TSFSTGSFFE LDGRPFCELH YHHRRGTLCH GCGQPITGRC ISAMGYKFHP EHFVCAFCLT
   361  QLSKGIFREQ NDKTYCQPCF NKLFPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPXN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
111 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 111 nTPM
  • thymus: 96 nTPM
  • lymph node: 81 nTPM
  • appendix: 46 nTPM
  • spleen: 42 nTPM
  • lung: 32 nTPM

Single-cell type

  • monocytes: 367 nCPM
  • innate lymphoid cells: 348 nCPM
  • pdcs: 296 nCPM
  • macrophages: 192 nCPM
  • cdc: 191 nCPM
  • plasma cells: 184 nCPM

Immune cell

  • T-reg: 153 nTPM
  • MAIT T-cell: 149 nTPM
  • myeloid DC: 138 nTPM
  • plasmacytoid DC: 125 nTPM
  • memory CD8 T-cell: 118 nTPM
  • memory CD4 T-cell: 103 nTPM

Brain region

  • white matter: 21 nTPM
  • thalamus: 19 nTPM
  • pons: 18 nTPM
  • cerebral cortex: 18 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LPXN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPXN as an antibody target. Whether an autoantibody or antibody against LPXN could matter depends on whether native LPXN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPXN is annotated at the cell surface, where native LPXN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPXN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPXN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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