Seroatlas · Human Serome Atlas

CSF2RB

Cytokine receptor common subunit beta

Also known as: betaGMR, CD131, IL3RB, IL3RB_HUMAN, IL5RB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32927
Gene
CSF2RB
Ensembl
ENSG00000100368
Chromosome
22
Canonical length
897 aa
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

897 residues, UniProt reviewed canonical sequence.

>P32927|CSF2RB
     1  MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT
    61  LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG
   121  TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD
   181  SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG
   241  DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL
   301  HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET
   361  MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG
   421  YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN
   481  PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE
   541  DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR
   601  SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ
   661  GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT
   721  PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP
   781  RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS
   841  SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALKQQ DYLSLPPWEV NKPGEVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSF2RB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 62 nTPM
  • tonsil: 59 nTPM
  • bone marrow: 51 nTPM
  • lymph node: 38 nTPM
  • placenta: 30 nTPM
  • spleen: 22 nTPM

Single-cell type

  • neutrophils: 511 nCPM
  • pdcs: 101 nCPM
  • megakaryocyte-erythroid progenitors: 77 nCPM
  • extravillous trophoblasts: 74 nCPM
  • late spermatids: 71 nCPM
  • mast cells: 68 nCPM

Immune cell

  • basophil: 239 nTPM
  • neutrophil: 76 nTPM
  • eosinophil: 24 nTPM
  • plasmacytoid DC: 15 nTPM
  • total PBMC: 10 nTPM
  • classical monocyte: 9.1 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • pons: 7 nTPM
  • thalamus: 7 nTPM
  • white matter: 6.5 nTPM
  • medulla oblongata: 6.1 nTPM
  • spinal cord: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSF2RB.

Disease | AllUniProt

Conditions CSF2RB is implicated in, by any mechanism.

  • Pulmonary surfactant metabolism dysfunction 5 (SMDP5) MIM:614370

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 883 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Surfactant metabolism dysfunction, pulmonary, 5

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.18
gnomAD missense Z
0.13
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSF2RB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSF2RB as an antibody target. Whether an autoantibody or antibody against CSF2RB could matter depends on whether native CSF2RB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSF2RB is annotated at the cell surface, where native CSF2RB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CSF2RB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSF2RB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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