Seroatlas · Human Serome Atlas

SKAP1

Src kinase-associated phosphoprotein 1

Also known as: SCAP1, SKAP1_HUMAN, SKAP55

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WV1
Gene
SKAP1
Ensembl
ENSG00000141293
Chromosome
17
Canonical length
359 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q86WV1|SKAP1
     1  MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG
    61  GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD
   121  HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY GVRMAPHLRR DSKKESCFEL
   181  TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS
   241  PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGVDYASYYQ
   301  GLWDCHGDQP DELSFQRGDL IRILSKEYNM YGWWVGELNS LVGIVPKEYL TTAFEVEER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 33 nTPM
  • lymph node: 27 nTPM
  • tonsil: 25 nTPM
  • epididymis: 16 nTPM
  • parathyroid gland: 13 nTPM
  • fallopian tube: 13 nTPM

Single-cell type

  • nk-cells: 1,237 nCPM
  • t-cells: 1,059 nCPM
  • mast cells: 496 nCPM
  • renal collecting duct intercalated cells: 494 nCPM
  • distal convoluted tubule cells: 409 nCPM
  • innate lymphoid cells: 386 nCPM

Immune cell

  • T-reg: 270 nTPM
  • gdT-cell: 171 nTPM
  • memory CD8 T-cell: 156 nTPM
  • MAIT T-cell: 145 nTPM
  • memory CD4 T-cell: 140 nTPM
  • naive CD8 T-cell: 136 nTPM

Brain region

  • spinal cord: 3 nTPM
  • medulla oblongata: 1.5 nTPM
  • hypothalamus: 1.3 nTPM
  • pons: 1 nTPM
  • white matter: 0.9 nTPM
  • hippocampal formation: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKAP1 as an antibody target. Whether an autoantibody or antibody against SKAP1 could matter depends on whether native SKAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKAP1 is annotated at the cell surface, where native SKAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SKAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SKAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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