Seroatlas · Human Serome Atlas

LILRB3

Leukocyte immunoglobulin-like receptor subfamily B member 3

Also known as: CD85a, HL9, ILT5, LIR-3, LIR3, LIRB3_HUMAN, PIR-B, PIRB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75022
Gene: LILRB3
Ensembl: ENSG00000204577
Chromosome: 19
Canonical length: 631 aa
Protein class: CD markers, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>O75022|LILRB3
     1  MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSQEAQEYRL
    61  HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY YSSAGWSEPS DPLEMVMTGA
   121  YSKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL
   181  FPVGPVTPSH RWRFTCYYYY TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS
   241  LTLQCGSDVG YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH
   301  NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ FDTFLLTKEG
   361  AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPHLLSHP SEPLELVVSG
   421  HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT
   481  DFQRPAGAAE TEPKDRGLLR RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA
   541  VTYAPVKHSS PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS
   601  LTLRRKATEP PPSQEGEPPA EPSIYATLAI H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spleen: 38 nTPM
lung: 19 nTPM
bone marrow: 12 nTPM
adipose tissue: 7.2 nTPM
appendix: 6.8 nTPM
blood vessel: 4.2 nTPM

Single-cell type

neutrophils: 61 nCPM
monocytes: 21 nCPM
macrophages: 5.9 nCPM
cdc: 4.8 nCPM
hofbauer cells: 4.6 nCPM
neutrophil progenitors: 2.5 nCPM

Immune cell

neutrophil: 43 nTPM
classical monocyte: 15 nTPM
intermediate monocyte: 15 nTPM
total PBMC: 11 nTPM
myeloid DC: 7.2 nTPM
non-classical monocyte: 6 nTPM

Brain region

thalamus: 4.5 nTPM
cerebral cortex: 4.1 nTPM
pons: 2.9 nTPM
white matter: 2.9 nTPM
medulla oblongata: 2.7 nTPM
choroid plexus: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LILRB3.

Disease | ImmuneIEDB

Conditions an epitope on LILRB3 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: -1.01
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LILRB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LILRB3 as an antibody target. Whether an autoantibody or antibody against LILRB3 could matter depends on whether native LILRB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LILRB3 is annotated at the cell surface, where native LILRB3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LILRB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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