CD24
Signal transducer CD24
Also known as: CD24_HUMAN, CD24A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P25063
- Gene
- CD24
- Ensembl
- ENSG00000272398
- Chromosome
- 6
- Canonical length
- 80 aa
- Protein class
- Cancer-related genes, CD markers, Disease related genes, Predicted intracellular proteins
- Subcellular location
- Vesicles
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Canonical amino-acid sequenceUniProt
80 residues, UniProt reviewed canonical sequence.
>P25063|CD24
1 MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNSGLAPNP TNATTKAAGG
61 ALQSTASLFV VSLSLLHLYSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CD24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 1,528 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 1,528 nTPM
- esophagus: 1,360 nTPM
- pancreas: 1,305 nTPM
- colon: 1,004 nTPM
- salivary gland: 913 nTPM
- gallbladder: 820 nTPM
Single-cell type
- esophageal apical cells: 14,637 nCPM
- esophageal suprabasal cells: 3,732 nCPM
- breast lactating cells: 3,587 nCPM
- pancreatic acinar cells: 2,830 nCPM
- parietal cells: 1,943 nCPM
- salivary duct cells: 1,892 nCPM
Immune cell
- eosinophil: 86 nTPM
- memory B-cell: 61 nTPM
- naive B-cell: 40 nTPM
- neutrophil: 2.1 nTPM
- total PBMC: 2 nTPM
- basophil: 0.3 nTPM
Brain region
- white matter: 105 nTPM
- hippocampal formation: 93 nTPM
- hypothalamus: 82 nTPM
- choroid plexus: 78 nTPM
- cerebral cortex: 63 nTPM
- basal ganglia: 60 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CD24.
Disease | AllUniProt
Conditions CD24 is implicated in, by any mechanism.
- Multiple sclerosis (MS) MIM:126200
OntologyGO
Biological processes
- cell activation
- cell migration
- cell-cell adhesion
- cholesterol homeostasis
- glomerular parietal epithelial cell differentiation
- immune response-regulating cell surface receptor signaling pathway
- intrinsic apoptotic signaling pathway
- podocyte differentiation
- positive regulation of activated T cell proliferation
- positive regulation of cytosolic calcium ion concentration
- positive regulation of nephron tubule epithelial cell differentiation
- regulation of cell-cell adhesion
- regulation of cytokine-mediated signaling pathway
- regulation of epithelial cell differentiation
- regulation of MAPK cascade
- respiratory burst
- response to estrogen
- response to hypoxia
- response to molecule of bacterial origin
- T cell costimulation
- Wnt signaling pathway
- B cell receptor transport into membrane raft
- chemokine receptor transport out of membrane raft
- negative regulation of transforming growth factor beta3 production
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Signal transducer CD24
- CD24 protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CD24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CD24 as an antibody target. Whether an autoantibody or antibody against CD24 could matter depends on whether native CD24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CD24 is annotated at the cell surface, where native CD24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CD24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...