Seroatlas · Human Serome Atlas

SYK

Tyrosine-protein kinase SYK

Also known as: KSYK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43405
Gene
SYK
Ensembl
ENSG00000165025
Chromosome
9
Canonical length
635 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>P43405|SYK
     1  MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
    61  AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF
   121  EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ
   181  IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL
   241  VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK
   301  PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP
   361  KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE
   421  ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM
   481  GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA
   541  PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE
   601  MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 82 nTPM
  • tonsil: 69 nTPM
  • lymph node: 58 nTPM
  • bone marrow: 48 nTPM
  • thymus: 46 nTPM
  • appendix: 40 nTPM

Single-cell type

  • neutrophil progenitors: 1,148 nCPM
  • neutrophils: 861 nCPM
  • microglia: 687 nCPM
  • monocyte progenitors: 604 nCPM
  • monocytes: 415 nCPM
  • macrophages: 326 nCPM

Immune cell

  • neutrophil: 112 nTPM
  • myeloid DC: 85 nTPM
  • eosinophil: 84 nTPM
  • classical monocyte: 77 nTPM
  • memory B-cell: 75 nTPM
  • intermediate monocyte: 64 nTPM

Brain region

  • white matter: 19 nTPM
  • thalamus: 13 nTPM
  • medulla oblongata: 13 nTPM
  • spinal cord: 12 nTPM
  • pons: 11 nTPM
  • midbrain: 9.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYK.

Disease | AllUniProt

Conditions SYK is implicated in, by any mechanism.

  • Immunodeficiency 82 with systemic inflammation (IMD82) MIM:619381

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.9
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYK as an antibody target. Whether an autoantibody or antibody against SYK could matter depends on whether native SYK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYK is annotated at the cell surface, where native SYK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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