CD79A

Protein identityUniProt · HPA

UniProt accession

P11912

Gene

CD79A

Ensembl

ENSG00000105369

Chromosome

19

Canonical length

226 aa

Protein class

Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>P11912|CD79A
     1  MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA HFQCPHNSSN
    61  NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH GGIYVCRVQE GNESYQQSCG
   121  TYLRVRQPPP RPFLDMGEGT KNRIITAEGI ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD
   181  EYEDENLYEG LNLDDCSMYE DISRGLQGTY QDVGSLNIGD VQLEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD79A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

510 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD79A.

Disease | AllUniProt

Conditions CD79A is implicated in, by any mechanism.

• Agammaglobulinemia 3, autosomal recessive (AGM3) MIM:613501

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 185 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Agammaglobulinemia 3, autosomal recessive
• Inherited Immunodeficiency Diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0.69

gnomAD missense Z

1.13

DepMap mean gene effect

0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• B cell activation
• B cell differentiation
• B cell proliferation
• B cell receptor signaling pathway

Molecular functions

• identical protein binding
• transmembrane signaling receptor activity

Cellular components

• B cell receptor complex
• external side of plasma membrane
• IgM B cell receptor complex
• membrane raft
• multivesicular body
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphorylated immunoreceptor signalling ITAM
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoreceptor tyrosine-based activation motif
• Immunoglobulin domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Membrane
• Methylation
• Phosphoprotein
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CD79A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LYN
• BLK
• FYN