Seroatlas · Human Serome Atlas

PPP1R15A

Protein phosphatase 1 regulatory subunit 15A

Also known as: GADD34, PR15A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75807
Gene: PPP1R15A
Ensembl: ENSG00000087074
Chromosome: 19
Canonical length: 674 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>O75807|PPP1R15A
     1  MAPGQAPHQA TPWRDAHPFF LLSPVMGLLS RAWSRLRGLG PLEPWLVEAV KGAALVEAGL
    61  EGEARTPLAI PHTPWGRRPE EEAEDSGGPG EDRETLGLKT SSSLPEAWGL LDDDDGMYGE
   121  REATSVPRGQ GSQFADGQRA PLSPSLLIRT LQGSDKNPGE EKAEEEGVAE EEGVNKFSYP
   181  PSHRECCPAV EEEDDEEAVK KEAHRTSTSA LSPGSKPSTW VSCPGEEENQ ATEDKRTERS
   241  KGARKTSVSP RSSGSDPRSW EYRSGEASEE KEEKAHKETG KGEAAPGPQS SAPAQRPQLK
   301  SWWCQPSDEE EGEVKALGAA EKDGEAECPP CIPPPSAFLK AWVYWPGEDT EEEEDEEEDE
   361  DSDSGSDEEE GEAEASSSTP ATGVFLKSWV YQPGEDTEEE EDEDSDTGSA EDEREAETSA
   421  STPPASAFLK AWVYRPGEDT EEEEDEDVDS EDKEDDSEAA LGEAESDPHP SHPDQRAHFR
   481  GWGYRPGKET EEEEAAEDWG EAEPCPFRVA IYVPGEKPPP PWAPPRLPLR LQRRLKRPET
   541  PTHDPDPETP LKARKVRFSE KVTVHFLAVW AGPAQAARQG PWEQLARDRS RFARRITQAQ
   601  EELSPCLTPA ARARAWARLR NPPLAPIPAL TQTLPSSSVP SSPVQTTPLS QAVATPSRSS
   661  AAAAAALDLS GRRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R15A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 529 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 529 nTPM
lung: 218 nTPM
adipose tissue: 190 nTPM
skin: 187 nTPM
heart muscle: 181 nTPM
blood vessel: 150 nTPM

Single-cell type

epididymal basal cells: 1,708 nCPM
neutrophils: 1,637 nCPM
endometrial luminal cells: 1,140 nCPM
endometrial glandular cells: 1,034 nCPM
endometrial secretory cells: 921 nCPM
epididymal efferent duct ciliated cells: 874 nCPM

Immune cell

neutrophil: 335 nTPM
basophil: 162 nTPM
plasmacytoid DC: 114 nTPM
eosinophil: 91 nTPM
classical monocyte: 49 nTPM
non-classical monocyte: 38 nTPM

Brain region

choroid plexus: 97 nTPM
cerebral cortex: 76 nTPM
white matter: 56 nTPM
cerebellum: 54 nTPM
medulla oblongata: 54 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R15A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R15A as an antibody target. Whether an autoantibody or antibody against PPP1R15A could matter depends on whether native PPP1R15A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R15A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R15A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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