Seroatlas · Human Serome Atlas

TOM1L1

TOM1-like protein 1

Also known as: SRCASM, TM1L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75674
Gene: TOM1L1
Ensembl: ENSG00000141198
Chromosome: 17
Canonical length: 476 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>O75674|TOM1L1
     1  MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK DAVKALKKRI
    61  SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN LVKLLNPRYN LPLDIQNRIL
   121  NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG VQFPPSEAEA ETARQETAQI SSNPPTSVPT
   181  APALSSVIAP KNSTVTLVPE QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ
   241  KLYKTGREMQ ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ
   301  KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS SDVTNNLKPS
   361  LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN SVFLQPVSLQ TIAAAPSNQS
   421  LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL APAVTTEAIY EEIDAHQHKG AQNDGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOM1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

liver: 101 nTPM
duodenum: 101 nTPM
kidney: 73 nTPM
parathyroid gland: 61 nTPM
small intestine: 57 nTPM
thyroid gland: 54 nTPM

Single-cell type

late spermatids: 310 nCPM
retinal horizontal cells: 254 nCPM
distal convoluted tubule cells: 194 nCPM
proximal tubule cells: 182 nCPM
mucous neck cells: 180 nCPM
renal connecting tubule cells: 176 nCPM

Immune cell

plasmacytoid DC: 0.6 nTPM
MAIT T-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

choroid plexus: 52 nTPM
cerebellum: 26 nTPM
cerebral cortex: 24 nTPM
spinal cord: 24 nTPM
hypothalamus: 23 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

VHS domain
GAT domain
ENTH/VHS
Target of Myb protein 1
GAT domain superfamily
VHS domain
GAT domain
TOM1-like protein 1, GAT domain
TOM1-like protein 1, VHS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOM1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOM1L1 as an antibody target. Whether an autoantibody or antibody against TOM1L1 could matter depends on whether native TOM1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOM1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOM1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...