Seroatlas · Human Serome Atlas

CD36

Platelet glycoprotein 4

Also known as: CD36_HUMAN, FAT, GP3B, GP4, GPIV, SCARB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16671
Gene
CD36
Ensembl
ENSG00000135218
Chromosome
7
Canonical length
472 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>P16671|CD36
     1  MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE
    61  VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENVTQDAEDN TVSFLQPNGA
   121  IFEPSLSVGT EADNFTVLNL AVAAASHIYQ NQFVQMILNS LINKSKSSMF QVRTLRELLW
   181  GYRDPFLSLV PYPVTTTVGL FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE
   241  SHCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
   301  ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL
   361  NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI VPILWLNETG
   421  TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
1,439 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 1,439 nTPM
  • breast: 534 nTPM
  • heart muscle: 507 nTPM
  • placenta: 388 nTPM
  • tongue: 356 nTPM
  • spleen: 292 nTPM

Single-cell type

  • hofbauer cells: 3,461 nCPM
  • breast lactating cells: 2,901 nCPM
  • adipocytes: 2,203 nCPM
  • myonuclei: 2,065 nCPM
  • erythrocyte progenitors: 1,495 nCPM
  • cardiomyocytes: 1,067 nCPM

Immune cell

  • classical monocyte: 965 nTPM
  • total PBMC: 693 nTPM
  • myeloid DC: 508 nTPM
  • intermediate monocyte: 271 nTPM
  • plasmacytoid DC: 129 nTPM
  • non-classical monocyte: 72 nTPM

Brain region

  • thalamus: 53 nTPM
  • medulla oblongata: 48 nTPM
  • midbrain: 44 nTPM
  • spinal cord: 31 nTPM
  • pons: 19 nTPM
  • hypothalamus: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD36.

Disease | AllUniProt

Conditions CD36 is implicated in, by any mechanism.

Disease | GeneticClinVar

53 pathogenic / likely-pathogenic of 316 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Platelet-type bleeding disorder 10
  • CD36-related disorder
  • Malaria, susceptibility to
  • Coronary heart disease, susceptibility to, 7
  • See cases

Disease | ImmuneIEDB

Conditions an epitope on CD36 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against CD36 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for CD36 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

15 publications

Show 10 more

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
2
gnomAD pLI
0
gnomAD missense Z
-4.28
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD36 as an antibody target. Whether an autoantibody or antibody against CD36 could matter depends on whether native CD36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD36 is annotated at the cell surface, where native CD36 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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