Seroatlas · Human Serome Atlas

PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Also known as: CBP, PAG, PHAG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWQ8
Gene: PAG1
Ensembl: ENSG00000076641
Chromosome: 8
Canonical length: 432 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q9NWQ8|PAG1
     1  MGPAGSLLGS GQMQITLWGS LAAVAIFFVI TFLIFLCSSC DREKKPRQHS GDHENLMNVP
    61  SDKEMFSRSV TSLATDAPAS SEQNGALTNG DILSEDSTLT CMQHYEEVQT SASDLLDSQD
   121  STGKPKCHQS RELPRIPPES AVDTMLTARS VDGDQGLGME GPYEVLKDSS SQENMVEDCL
   181  YETVKEIKEV AAAAHLEKGH SGKAKSTSAS KELPGPQTEG KAEFAEYASV DRNKKCRQSV
   241  NVESILGNSC DPEEEAPPPV PVKLLDENEN LQEKEGGEAE ESATDTTSET NKRFSSLSYK
   301  SREEDPTLTE EEISAMYSSV NKPGQLVNKS GQSLTVPEST YTSIQGDPQR SPSSCNDLYA
   361  TVKDFEKTPN STLPPAGRPS EEPEPDYEAI QTLNREEEKA TLGTNGHHGL VPKENDYESI
   421  SDLQQGRDIT RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

placenta: 15 nTPM
lung: 14 nTPM
pancreas: 14 nTPM
lymph node: 14 nTPM
cerebellum: 13 nTPM
tonsil: 13 nTPM

Single-cell type

neutrophils: 2,606 nCPM
neutrophil progenitors: 1,964 nCPM
melanocytes: 843 nCPM
mast cells: 613 nCPM
microglia: 549 nCPM
monocytes: 467 nCPM

Immune cell

non-classical monocyte: 15 nTPM
basophil: 13 nTPM
T-reg: 7.2 nTPM
intermediate monocyte: 6.4 nTPM
memory CD4 T-cell: 6.2 nTPM
MAIT T-cell: 6.1 nTPM

Brain region

cerebellum: 34 nTPM
white matter: 16 nTPM
thalamus: 14 nTPM
spinal cord: 14 nTPM
pons: 14 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.02
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Phosphoprotein associated with glycosphingolipid-enriched

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAG1 as an antibody target. Whether an autoantibody or antibody against PAG1 could matter depends on whether native PAG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAG1 is annotated at the cell surface, where native PAG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PAG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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