Seroatlas · Human Serome Atlas

NCOA3

Nuclear receptor coactivator 3

Also known as: ACTR, AIB1, bHLHe42, CAGH16, KAT13B, NCOA3_HUMAN, p/CIP, RAC3, SRC-3, SRC3, TNRC16, TRAM-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6Q9
Gene: NCOA3
Ensembl: ENSG00000124151
Chromosome: 20
Canonical length: 1424 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

1424 residues, UniProt reviewed canonical sequence.

>Q9Y6Q9|NCOA3
     1  MSGLGENLDP LASDSRKRKL PCDTPGQGLT CSGEKRRREQ ESKYIEELAE LISANLSDID
    61  NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV SSTGQGVIDK DSLGPLLLQA
   121  LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE DLVNTSVYNI LHEEDRKDFL KNLPKSTVNG
   181  VSWTNETQRQ KSHTFNCRML MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE
   241  DLQSCMICVA RRITTGERTF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC
   301  IQRFFSLNDG QSWSQKRHYQ EAYLNGHAET PVYRFSLADG TIVTAQTKSK LFRNPVTNDR
   361  HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGG MSMSPNQGLQ MPSSRAYGLA
   421  DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS PSSYQNNNYG LNMSSPPHGS PGLAPNQQNI
   481  MISPRNRGSP KIASHQFSPV AGVHSPMASS GNTGNHSFSS SSLSALQAIS EGVGTSLLST
   541  LSSPGPKLDN SPNMNITQPS KVSNQDSKSP LGFYCDQNPV ESSMCQSNSR DHLSDKESKE
   601  SSVEGAENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS VSVTSPSGVS
   661  SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK ITAEATGKDT SSITSCGDGN
   721  VVKQEQLSPK KKENNALLRY LLDRDDPSDA LSKELQPQVE GVDNKMSQCT SSTIPSSSQE
   781  KDPKIKTETS EEGSGDLDNL DAILGDLTSS DFYNNSISSN GSHLGTKQQV FQGTNSLGLK
   841  SSQSVQSIRP PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMDSQENYGS
   901  SMGGPNRNVT VTQTPSSGDW GLPNSKAGRM EPMNSNSMGR PGGDYNTSLP RPALGGSIPT
   961  LPLRSNSIPG ARPVLQQQQQ MLQMRPGEIP MGMGANPYGQ AAASNQLGSW PDGMLSMEQV
  1021  SHGTQNRPLL RNSLDDLVGP PSNLEGQSDE RALLDQLHTL LSNTDATGLE EIDRALGIPE
  1081  LVNQGQALEP KQDAFQGQEA AVMMDQKAGL YGQTYPAQGP PMQGGFHLQG QSPSFNSMMN
  1141  QMNQQGNFPL QGMHPRANIM RPRTNTPKQL RMQLQQRLQG QQFLNQSRQA LELKMENPTA
  1201  GGAAVMRPMM QPQVSSQQGF LNAQMVAQRS RELLSHHFRQ QRVAMMMQQQ QQQQQQQQQQ
  1261  QQQQQQQQQQ QQQQQQTQAF SPPPNVTASP SMDGLLAGPT MPQAPPQQFP YQPNYGMGQQ
  1321  PDPAFGRVSS PPNAMMSSRM GPSQNPMMQH PQAASIYQSS EMKGWPSGNL ARNSSFSQQQ
  1381  FAHQGNPAVY SMVHMNGSSG HMGQMNMNPM PMSGMPMGPD QKYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCOA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

tonsil: 37 nTPM
lymph node: 33 nTPM
placenta: 27 nTPM
spleen: 26 nTPM
skeletal muscle: 23 nTPM
appendix: 22 nTPM

Single-cell type

plasma cells: 861 nCPM
b-cells: 756 nCPM
endometrial glandular cells: 687 nCPM
syncytiotrophoblasts: 481 nCPM
myonuclei: 432 nCPM
neutrophils: 400 nCPM

Immune cell

memory B-cell: 9.3 nTPM
naive B-cell: 6.8 nTPM
intermediate monocyte: 5.2 nTPM
non-classical monocyte: 5.1 nTPM
myeloid DC: 5 nTPM
neutrophil: 4.5 nTPM

Brain region

cerebral cortex: 22 nTPM
pons: 18 nTPM
white matter: 17 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
cerebellum: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NCOA3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Bilateral sensorineural hearing impairment

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.54
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCOA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCOA3 as an antibody target. Whether an autoantibody or antibody against NCOA3 could matter depends on whether native NCOA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCOA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCOA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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