STOML1
Stomatin-like protein 1
Also known as: FLJ36370, hUNC-24, SLP-1, STML1_HUMAN, STORP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UBI4
- Gene
- STOML1
- Ensembl
- ENSG00000067221
- Chromosome
- 15
- Canonical length
- 398 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable ion channel inhibitor activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
398 residues, UniProt reviewed canonical sequence.
>Q9UBI4|STOML1
1 MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPERGGV GTGADVPQSW PSCLCHGLIS
61 FLGFLLLLVT FPISGWFALK IVPTYERMIV FRLGRIRTPQ GPGMVLLLPF IDSFQRVDLR
121 TRAFNVPPCK LASKDGAVLS VGADVQFRIW DPVLSVMTVK DLNTATRMTA QNAMTKALLK
181 RPLREIQMEK LKISDQLLLE INDVTRAWGL EVDRVELAVE AVLQPPQDSP AGPNLDSTLQ
241 QLALHFLGGS MNSMAGGAPS PGPADTVEMV SEVEPPAPQV GARSSPKQPL AEGLLTALQP
301 FLSEALVSQV GACYQFNVVL PSGTQSAYFL DLTTGRGRVG HGVPDGIPDV VVEMAEADLR
361 ALLCRELRPL GAYMSGRLKV KGDLAMAMKL EAVLRALKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STOML1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 49 nTPM
- amygdala: 35 nTPM
- hippocampal formation: 35 nTPM
- basal ganglia: 35 nTPM
- hypothalamus: 32 nTPM
- spinal cord: 25 nTPM
Single-cell type
- breast lactating cells: 23 nCPM
- early primary spermatocytes: 22 nCPM
- decidual stromal cells: 20 nCPM
- retinal amacrine cells: 18 nCPM
- other brain neurons: 18 nCPM
- alveolar cells type 2: 17 nCPM
Immune cell
- non-classical monocyte: 18 nTPM
- plasmacytoid DC: 12 nTPM
- naive CD8 T-cell: 9.2 nTPM
- naive CD4 T-cell: 8.7 nTPM
- T-reg: 8.1 nTPM
- NK-cell: 8 nTPM
Brain region
- cerebral cortex: 59 nTPM
- pons: 58 nTPM
- medulla oblongata: 52 nTPM
- basal ganglia: 49 nTPM
- hypothalamus: 48 nTPM
- hippocampal formation: 47 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.57
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.43
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of STOML1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STOML1 as an antibody target. Whether an autoantibody or antibody against STOML1 could matter depends on whether native STOML1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STOML1 is annotated at the cell surface, where native STOML1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label STOML1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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