SPDYC
Speedy protein C
Also known as: Ringo2, SPDYC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5MJ68
- Gene
- SPDYC
- Ensembl
- ENSG00000204710
- Chromosome
- 11
- Canonical length
- 274 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables protein kinase binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
274 residues, UniProt reviewed canonical sequence.
>Q5MJ68|SPDYC
1 MSDSQDPTTS PVVTTQVELG GCSRQGGGNG FLRFRQHQEV QAFLSLLEDS FVQEFLSKDP
61 CFQISDKYLL AMVLVYFQRA HLKLSEYTHS SLFLALYLAN DMEEDLEGPK CEIFPWALGK
121 DWCLRVGKFL HQRDKLWARM GFRAVVSRQC CEEVMAKEPF HWAWTRDRRP HHGGVQRVCP
181 QVPVRLPRGP GLSPPHCSPC GLPQHCSSHL LKPVSSKCPS LTSECHRPPS QNYLSRVKNA
241 WGGDFLIVLP PQMQLEPGTY SLRIFPKPPA RPGHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPDYC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 2.9 nTPM
Expression across tissuesHPA
Tissue
- liver: 2.9 nTPM
- testis: 0.9 nTPM
- epididymis: 0.3 nTPM
- skeletal muscle: 0.2 nTPM
- gallbladder: 0.1 nTPM
- kidney: 0.1 nTPM
Single-cell type
- platelets: 55 nCPM
- late spermatids: 18 nCPM
- oocytes: 9.2 nCPM
- extravillous trophoblasts: 8.4 nCPM
- megakaryocytes: 6.2 nCPM
- syncytiotrophoblasts: 5.8 nCPM
Immune cell
- total PBMC: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- medulla oblongata: 0.9 nTPM
- cerebral cortex: 0.7 nTPM
- thalamus: 0.7 nTPM
- basal ganglia: 0.6 nTPM
- hippocampal formation: 0.6 nTPM
- hypothalamus: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.05
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.5
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPDYC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPDYC as an antibody target. Whether an autoantibody or antibody against SPDYC could matter depends on whether native SPDYC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPDYC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPDYC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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