Seroatlas · Human Serome Atlas

CCNH

Cyclin-H

Also known as: CCNH_HUMAN, CycH, p34, p37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51946
Gene: CCNH
Ensembl: ENSG00000134480
Chromosome: 5
Canonical length: 323 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P51946|CCNH
     1  MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY
    61  EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV
   121  SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI
   181  LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE
   241  NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD
   301  DYVSKKSKHE EEEWTDDDLV ESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

testis: 51 nTPM
adipose tissue: 37 nTPM
bone marrow: 36 nTPM
liver: 35 nTPM
thymus: 34 nTPM
breast: 29 nTPM

Single-cell type

neutrophils: 1,359 nCPM
vascular smooth muscle cells: 887 nCPM
innate lymphoid cells: 848 nCPM
t-cells: 769 nCPM
mast cells: 761 nCPM
adipocytes: 656 nCPM

Immune cell

eosinophil: 59 nTPM
non-classical monocyte: 50 nTPM
basophil: 50 nTPM
intermediate monocyte: 47 nTPM
T-reg: 45 nTPM
myeloid DC: 45 nTPM

Brain region

cerebellum: 34 nTPM
cerebral cortex: 25 nTPM
white matter: 24 nTPM
hypothalamus: 21 nTPM
hippocampal formation: 20 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -1.24
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNH as an antibody target. Whether an autoantibody or antibody against CCNH could matter depends on whether native CCNH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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