Seroatlas · Human Serome Atlas

CKS2

Cyclin-dependent kinases regulatory subunit 2

Also known as: CKS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P33552
Gene: CKS2
Ensembl: ENSG00000123975
Chromosome: 9
Canonical length: 79 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Mitochondria,Cytosol
Quaternary structure: Homohexamer

OverviewNCBI Gene

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P33552|CKS2
     1  MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH
    61  EPEPHILLFR RPLPKDQQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CKS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

testis: 176 nTPM
bone marrow: 167 nTPM
thymus: 113 nTPM
lymph node: 96 nTPM
tonsil: 79 nTPM
adrenal gland: 78 nTPM

Single-cell type

late primary spermatocytes: 1,010 nCPM
oocytes: 741 nCPM
differentiating spermatogonia: 610 nCPM
early primary spermatocytes: 578 nCPM
gastric progenitor cells: 481 nCPM
granulosa cells: 440 nCPM

Immune cell

plasmacytoid DC: 188 nTPM
T-reg: 63 nTPM
memory B-cell: 62 nTPM
naive B-cell: 45 nTPM
eosinophil: 44 nTPM
basophil: 41 nTPM

Brain region

cerebral cortex: 15 nTPM
hippocampal formation: 9.1 nTPM
choroid plexus: 8.3 nTPM
cerebellum: 7.6 nTPM
white matter: 6.4 nTPM
pons: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CKS2.

Disease | ImmuneIEDB

Conditions an epitope on CKS2 was assayed in.

pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.42
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CKS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CKS2 as an antibody target. Whether an autoantibody or antibody against CKS2 could matter depends on whether native CKS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CKS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CKS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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