Seroatlas · Human Serome Atlas

CDK3

Cyclin-dependent kinase 3

Also known as: CDK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00526
Gene: CDK3
Ensembl: ENSG00000250506
Chromosome: 17
Canonical length: 305 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q00526|CDK3
     1  MDMFQKVEKI GEGTYGVVYK AKNRETGQLV ALKKIRLDLE MEGVPSTAIR EISLLKELKH
    61  PNIVRLLDVV HNERKLYLVF EFLSQDLKKY MDSTPGSELP LHLIKSYLFQ LLQGVSFCHS
   121  HRVIHRDLKP QNLLINELGA IKLADFGLAR AFGVPLRTYT HEVVTLWYRA PEILLGSKFY
   181  TTAVDIWSIG CIFAEMVTRK ALFPGDSEID QLFRIFRMLG TPSEDTWPGV TQLPDYKGSF
   241  PKWTRKGLEE IVPNLEPEGR DLLMQLLQYD PSQRITAKTA LAHPYFSSPE PSPAARQYVL
   301  QRFRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

liver: 34 nTPM
prostate: 25 nTPM
skin: 23 nTPM
spleen: 21 nTPM
pituitary gland: 19 nTPM
thyroid gland: 19 nTPM

Single-cell type

proximal tubule cells: 12 nCPM
podocytes: 9.8 nCPM
renal connecting tubule cells: 8 nCPM
distal convoluted tubule cells: 7.5 nCPM
astrocytes: 7 nCPM
papillary tip epithelial cells: 6.7 nCPM

Immune cell

T-reg: 0.4 nTPM
naive CD4 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 8.1 nTPM
cerebral cortex: 5.7 nTPM
medulla oblongata: 5.1 nTPM
hypothalamus: 5 nTPM
choroid plexus: 4.9 nTPM
pons: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK3 as an antibody target. Whether an autoantibody or antibody against CDK3 could matter depends on whether native CDK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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