Seroatlas · Human Serome Atlas

LIN37

Protein lin-37 homolog

Also known as: F25965, lin-37, LIN37_HUMAN, ZK418.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GY3
Gene: LIN37
Ensembl: ENSG00000267796
Chromosome: 19
Canonical length: 246 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q96GY3|LIN37
     1  MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD THNKDCSIAA
    61  TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF DRSVDLAQFS ENTPLYPICR
   121  AWMRNSPSVR ERECSPSSPL PPLPEDEEGS EVTNSKSRDV YKLPPPTPPG PPGDACRSRI
   181  PSPLQPEMQG TPDDEPSEPE PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR
   241  EMYERQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
skeletal muscle: 22 nTPM
ovary: 22 nTPM
blood vessel: 21 nTPM
basal ganglia: 20 nTPM
cerebral cortex: 19 nTPM

Single-cell type

foveolar cells: 1 nCPM
lacrimal acinar cells: 0.9 nCPM
leydig cells: 0.9 nCPM
enterocytes: 0.8 nCPM
goblet cells: 0.7 nCPM
syncytiotrophoblasts: 0.6 nCPM

Immune cell

neutrophil: 32 nTPM
eosinophil: 26 nTPM
T-reg: 22 nTPM
memory CD8 T-cell: 21 nTPM
naive CD4 T-cell: 21 nTPM
memory CD4 T-cell: 20 nTPM

Brain region

cerebral cortex: 19 nTPM
cerebellum: 18 nTPM
hypothalamus: 18 nTPM
basal ganglia: 17 nTPM
thalamus: 17 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.01
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein LIN37
LIN37

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN37 as an antibody target. Whether an autoantibody or antibody against LIN37 could matter depends on whether native LIN37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIN37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...