Seroatlas · Human Serome Atlas

CABLES1

CDK5 and ABL1 enzyme substrate 1

Also known as: CABL1_HUMAN, FLJ35924, HsT2563

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDN4
Gene: CABLES1
Ensembl: ENSG00000134508
Chromosome: 18
Canonical length: 633 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q8TDN4|CABLES1
     1  MAAAAAAATT AACSSGSAGT DAAGASGLQQ PPPQPQPQPA AAAPAQPPPE PPRKPRMDPR
    61  RRQAALSFLT NISLDGRLPP QDAEWGGGEE GGAAKPGAGG ACGARTRFSL LAAAERGGCI
   121  ALAAPGTPAA GLAAGSGPCL PQPSSLPPLI PGGHATVSGP GVARGFASPL GAGRASGEQW
   181  QPPRPAPLAA CAQLQLLDGS GAAGQEELEE DDAFISVQVP AAAFLGSGTP GSGSGSRGRL
   241  NSFTQGILPI AFSRPTSQNY CSLEQPGQGG STSAFEQLQR SRRRLISQRS SLETLEDIEE
   301  NAPLRRCRTL SGSPRPKNFK KIHFIKNMRQ HDTRNGRIVL ISGRRSFCSI FSVLPYRDST
   361  QVGDLKLDGG RQSTGAVSLK EIIGLEGVEL GADGKTVSYT QFLLPTNAFG ARRNTIDSTS
   421  SFSQFRNLSH RSLSIGRASG TQGSLDTGSD LGDFMDYDPN LLDDPQWPCG KHKRVLIFPS
   481  YMTTVIDYVK PSDLKKDMNE TFKEKFPHIK LTLSKIRSLK REMRKLAQED CGLEEPTVAM
   541  AFVYFEKLAL KGKLNKQNRK LCAGACVLLA AKIGSDLKKH EVKHLIDKLE EKFRLNRREL
   601  IAFEFPVLVA LEFALHLPEH EVMPHYRRLV QSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CABLES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 53 nTPM
cerebral cortex: 41 nTPM
amygdala: 39 nTPM
midbrain: 30 nTPM
salivary gland: 21 nTPM
parathyroid gland: 21 nTPM

Single-cell type

endometrial glandular cells: 1,282 nCPM
astrocytes: 534 nCPM
bergmann glia: 482 nCPM
endometrial luminal cells: 367 nCPM
melanocytes: 356 nCPM
hofbauer cells: 243 nCPM

Immune cell

NK-cell: 1.2 nTPM
gdT-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

hypothalamus: 108 nTPM
basal ganglia: 99 nTPM
thalamus: 97 nTPM
amygdala: 88 nTPM
midbrain: 86 nTPM
cerebral cortex: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.01
gnomAD missense Z: 1.73
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CABLES1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CABLES1 as an antibody target. Whether an autoantibody or antibody against CABLES1 could matter depends on whether native CABLES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CABLES1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CABLES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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