Seroatlas · Human Serome Atlas

TUBA1C

Tubulin alpha-1C chain

Also known as: bcm948, MGC10851, MGC14580, TBA1C_HUMAN, TUBA6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQE3
Gene
TUBA1C
Ensembl
ENSG00000167553
Chromosome
12
Canonical length
449 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Primary cilium

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in cilium; microtubule cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>Q9BQE3|TUBA1C
     1  MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK
    61  HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD
   121  RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
   181  VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA
   241  SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLTVAE ITNACFEPAN
   301  QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP
   361  TVVPGGDLAK VQRAVCMLSN TTAVAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
   421  AREDMAALEK DYEEVGADSA DGEDEGEEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBA1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
436 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 436 nTPM
  • urinary bladder: 207 nTPM
  • choroid plexus: 169 nTPM
  • tonsil: 160 nTPM
  • skin: 157 nTPM
  • vagina: 150 nTPM

Single-cell type

  • extravillous trophoblasts: 1,578 nCPM
  • megakaryocytes: 1,286 nCPM
  • esophageal apical cells: 1,230 nCPM
  • esophageal suprabasal cells: 1,116 nCPM
  • oocytes: 811 nCPM
  • esophageal basal cells: 703 nCPM

Immune cell

  • basophil: 99 nTPM
  • eosinophil: 30 nTPM
  • myeloid DC: 27 nTPM
  • plasmacytoid DC: 21 nTPM
  • total PBMC: 21 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • choroid plexus: 70 nTPM
  • thalamus: 31 nTPM
  • hypothalamus: 17 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 15 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBA1C.

Disease | AllUniProt

Conditions TUBA1C is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 24 (OZEMA24) MIM:621232

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.01
gnomAD missense Z
2.17
DepMap mean gene effect
-0.85
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBA1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBA1C as an antibody target. Whether an autoantibody or antibody against TUBA1C could matter depends on whether native TUBA1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBA1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBA1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBA1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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