Seroatlas · Human Serome Atlas

BORA

Protein aurora borealis

Also known as: BORA_HUMAN, C13orf34, FLJ22624

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PGQ7
Gene: BORA
Ensembl: ENSG00000136122
Chromosome: 13
Canonical length: 559 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q6PGQ7|BORA
     1  MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL PTPGKFRWSI
    61  DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI EEFFTKDVIV PSPWTDHEGK
   121  QLSQCHSSKC TNINSDSPVG KKLTIHSEKS DAACQTLLSL PVDFNLENIL GDYFRADEFA
   181  DQSPGNLSSS SLRRKLFLDG NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP
   241  LQTPSSGQFS SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP
   301  DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ IPFTLETQGE
   361  DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV VTAMSVTQNQ SSASEKELAL
   421  LQDVEREKDN NTVDMVDPIE IADETTWIKE PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL
   481  AESSVIPCES SNIQMDSGYN TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD
   541  HTTQRCWMKT ASPFQCSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BORA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

thymus: 7.5 nTPM
lymph node: 7.1 nTPM
tonsil: 6.4 nTPM
bone marrow: 5.7 nTPM
rectum: 4.7 nTPM
duodenum: 4.1 nTPM

Single-cell type

epicardial cells: 36 nCPM
late primary spermatocytes: 35 nCPM
sertoli cells: 31 nCPM
monocyte progenitors: 29 nCPM
cardiomyocytes: 29 nCPM
erythrocyte progenitors: 24 nCPM

Immune cell

naive CD8 T-cell: 2.5 nTPM
MAIT T-cell: 2.3 nTPM
memory CD8 T-cell: 2 nTPM
gdT-cell: 1.9 nTPM
intermediate monocyte: 1.9 nTPM
myeloid DC: 1.9 nTPM

Brain region

choroid plexus: 2.6 nTPM
medulla oblongata: 1.9 nTPM
pons: 1.6 nTPM
white matter: 1.6 nTPM
cerebellum: 1.5 nTPM
cerebral cortex: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.67
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Aurora borealis protein
Protein aurora borealis N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BORA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BORA as an antibody target. Whether an autoantibody or antibody against BORA could matter depends on whether native BORA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BORA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BORA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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