JTB
Protein JTB
Also known as: hJT, JTB_HUMAN, PAR
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O76095
- Gene
- JTB
- Ensembl
- ENSG00000143543
- Chromosome
- 1
- Canonical length
- 146 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted membrane proteins
- Subcellular location
- Vesicles,Mitochondria
OverviewNCBI Gene
Enables protein kinase binding activity. Involved in mitotic cytokinesis and positive regulation of protein kinase activity. Located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
146 residues, UniProt reviewed canonical sequence.
>O76095|JTB
1 MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC
61 SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF
121 ACLVIIRQRQ LDRKALEKVR KQIESILocalizationUniProt · AlphaFold · HPA
Whether an antibody against JTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 225 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 225 nTPM
- liver: 200 nTPM
- choroid plexus: 189 nTPM
- pituitary gland: 181 nTPM
- skeletal muscle: 162 nTPM
- stomach: 159 nTPM
Single-cell type
- gastric chief cells: 209 nCPM
- parietal cells: 140 nCPM
- mucous neck cells: 83 nCPM
- breast lactating cells: 69 nCPM
- breast secretory cells: 66 nCPM
- plasma cells: 63 nCPM
Immune cell
- eosinophil: 174 nTPM
- plasmacytoid DC: 148 nTPM
- memory B-cell: 144 nTPM
- naive B-cell: 141 nTPM
- classical monocyte: 120 nTPM
- memory CD8 T-cell: 119 nTPM
Brain region
- choroid plexus: 117 nTPM
- thalamus: 71 nTPM
- medulla oblongata: 68 nTPM
- basal ganglia: 65 nTPM
- spinal cord: 63 nTPM
- white matter: 62 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.66
- gnomAD pLI
- 0.42
- gnomAD missense Z
- 0.91
- DepMap mean gene effect
- -0.24
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic mitochondrial changes
- mitotic cell cycle
- mitotic cytokinesis
- positive regulation of protein kinase activity
- regulation of cell population proliferation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Jumping translocation breakpoint
- Jumping translocation breakpoint protein (JTB)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of JTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads JTB as an antibody target. Whether an autoantibody or antibody against JTB could matter depends on whether native JTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
JTB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label JTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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