Seroatlas · Human Serome Atlas

CIMAP3

Ciliary microtubule-associated protein 3

Also known as: C1orf88, CMAP3_HUMAN, FLJ23853, PIFO, pitchfork

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCI5
Gene: CIMAP3
Ensembl: ENSG00000173947
Chromosome: 1
Canonical length: 191 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables cytoskeletal protein binding activity and enzyme binding activity. Involved in positive regulation of kinase activity. Predicted to be located in ciliary basal body and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q8TCI5|CIMAP3
     1  MCFSRADAAD NYPFGTCQQR KLFPHFHPPN LIGNKFVPLR GSPHRGPGCY FSDGYGLAYD
    61  LSKIPTSIKG YTLGARTAVR FKPIQKEMTP HAGRYQKVSP QQEKHKQNFA PFNVLVPRFK
   121  NYPKDTYYPS PGAYNPEKKP PPKIAWPMKF GSPDWAQVPC LQKRTLKAEL STDKDFRKHR
   181  NRVAYLSLYY N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 164 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 164 nTPM
choroid plexus: 134 nTPM
testis: 23 nTPM
parathyroid gland: 14 nTPM
thyroid gland: 14 nTPM
hypothalamus: 13 nTPM

Single-cell type

fallopian tube ciliated cells: 1,265 nCPM
respiratory ciliated cells: 949 nCPM
epididymal efferent duct ciliated cells: 682 nCPM
late spermatids: 642 nCPM
endometrial ciliated cells: 542 nCPM
early spermatids: 495 nCPM

Immune cell

MAIT T-cell: 0.7 nTPM
memory B-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

choroid plexus: 66 nTPM
midbrain: 22 nTPM
medulla oblongata: 21 nTPM
white matter: 18 nTPM
spinal cord: 15 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sperm-tail PG-rich repeat
Sperm-tail PG-rich repeat
Ciliary microtubule-associated protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIMAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMAP3 as an antibody target. Whether an autoantibody or antibody against CIMAP3 could matter depends on whether native CIMAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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