Seroatlas · Human Serome Atlas

MYCN

N-myc proto-oncogene protein

Also known as: bHLHe37, MYCN_HUMAN, MYCNOT, N-myc, NMYC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04198
Gene
MYCN
Ensembl
ENSG00000134323
Chromosome
2
Canonical length
464 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>P04198|MYCN
     1  MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP
    61  LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG GLGGLTPNPV ILQDCMWSGF
   121  SAREKLERAV SEKLQHGRGP PTAGSTAQSP GAGAASPAGR GHGGAAGAGR AGAALPAELA
   181  HPAAECVDPA VVFPFPVNKR EPAPVPAAPA SAPAAGPAVA SGAGIAAPAG APGVAPPRPG
   241  GRQTSGGDHK ALSTSGEDTL SDSDDEDDEE EDEEEEIDVV TVEKRRSSSN TKAVTTFTIT
   301  VRPKNAALGP GRAQSSELIL KRCLPIHQQH NYAAPSPYVE SEDAPPQKKI KSEASPRPLK
   361  SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE LVKNEKAAKV
   421  VILKKATEYV HSLQAEEHQL LLEKEKLQAR QQQLLKKIEH ARTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
7.7 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 7.7 nTPM
  • spinal cord: 5.8 nTPM
  • salivary gland: 4.7 nTPM
  • hippocampal formation: 4.4 nTPM
  • ovary: 3.9 nTPM
  • midbrain: 3.7 nTPM

Single-cell type

  • extravillous trophoblasts: 124 nCPM
  • migrating cytotrophoblasts: 19 nCPM
  • hematopoietic stem cells: 16 nCPM
  • lymphatic endothelial cells: 12 nCPM
  • mucous neck cells: 12 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 10 nTPM
  • medulla oblongata: 7.4 nTPM
  • cerebral cortex: 6.5 nTPM
  • midbrain: 6.4 nTPM
  • pons: 6.3 nTPM
  • basal ganglia: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYCN.

Disease | AllUniProt

Conditions MYCN is implicated in, by any mechanism.

Disease | GeneticClinVar

72 pathogenic / likely-pathogenic of 374 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Feingold syndrome type 1
  • Inborn genetic diseases
  • Megalencephaly-polydactyly syndrome
  • MYCN-related disorder
  • Feingold syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.89
gnomAD missense Z
1.41
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYCN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYCN as an antibody target. Whether an autoantibody or antibody against MYCN could matter depends on whether native MYCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYCN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYCN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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