Seroatlas · Human Serome Atlas

CEP192

Centrosomal protein of 192 kDa

Also known as: CE192_HUMAN, FLJ10352, KIAA1569, PPP1R62

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEP8
Gene: CEP192
Ensembl: ENSG00000101639
Chromosome: 18
Canonical length: 2537 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and procentriole. Part of procentriole replication complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2537 residues, UniProt reviewed canonical sequence.

>Q8TEP8|CEP192
     1  MEDFRGIAEE SFPSFLTNSL FGNSGILENV TLSSNLGLPV AVSTLARDRS STDNRYPDIQ
    61  ASYLVEGRFS VPSGSSPGSQ SDAEPRERLQ LSFQDDDSIS RKKSYVESQR LSNALSKQSA
   121  LQMETAGPEE EPAGATESLQ GQDLFNRASP LEQAQDSPID FHLQSWMNNK EPKIVVLDAG
   181  KHFEDKTLKS DLSHTSLLEN EKLILPTSLE DSSDDDIDDE MFYDDHLEAY FEQLAIPGMI
   241  YEDLEGPEPP EKGFKLPTNG LRQANENGSL NCKFQSENNS SLISLDSHSS ETTHKESEES
   301  QVICLPGTSN SIGTGDSRRY TDGMLPFSSG TWGTEKEIEN LKGIVPDLNS ECASKDVLVK
   361  TLRAIDVKLN SDNFHDANAN RGGFDLTDPV KQGAECPHQN KTVLHMDGCL DTETPTVSIQ
   421  ENVDVASLKP ISDSGINFTD AIWSPTCERR TCECHESIEK NKDKTDLPQS VVYQNEEGRW
   481  VTDLAYYTSF NSKQNLNVSL SDEMNEDFRS GSEAFDLIAQ DEEEFNKEHQ FIQEENIDAH
   541  NTSVALGDTS WGATINYSLL RKSRSTSDLD KDDASYLRLS LGEFFAQRSE ALGCLGGGNN
   601  VKRPSFGYFI RSPEKREPIA LIRKSDVSRG NLEKEMAHLN HDLYSGDLNE QSQAQLSEGS
   661  ITLQVEAVES TSQVDENDVT LTADKGKTED TFFMSNKPQR YKDKLPDSGD SMLRISTIAS
   721  AIAEASVNTD PSQLAAMIKA LSNKTRDKTF QEDEKQKDYS HVRHFLPNDL EKSNGSNALD
   781  MEKYLKKTEV SRYESALENF SRASMSDTWD LSLPKEQTTQ DIHPVDLSAT SVSVRAPEEN
   841  TAAIVYVENG ESENQESFRT INSSNSVTNR ENNSAVVDVK TCSIDNKLQD VGNDEKATSI
   901  STPSDSYSSV RNPRITSLCL LKDCEEIRDN RENQRQNECV SEISNSEKHV TFENHRIVSP
   961  KNSDLKNTSP EHGGRGSEDE QESFRPSTSP LSHSSPSEIS GTSSSGCALE SFGSAAQQQQ
  1021  PPCEQELSPL VCSPAGVSRL TYVSEPESSY PTTATDDALE DRKSDITSEL STTIIQGSPA
  1081  ALEERAMEKL REKVPFQNRG KGTLSSIIQN NSDTRKATET TSLSSKPEYV KPDFRWSKDP
  1141  SSKSGNLLET SEVGWTSNPE ELDPIRLALL GKSGLSCQVG SATSHPVSCQ EPIDEDQRIS
  1201  PKDKSTAGRE FSGQVSHQTT SENQCTPIPS STVHSSVADM QNMPAAVHAL LTQPSLSAAP
  1261  FAQRYLGTLP STGSTTLPQC HAGNATVCGF SGGLPYPAVA GEPVQNSVAV GICLGSNIGS
  1321  GWMGTSSLCN PYSNTLNQNL LSTTKPFPVP SVGTNCGIEP WDSGVTSGLG SVRVPEELKL
  1381  PHACCVGIAS QTLLSVLNPT DRWLQVSIGV LSISVNGEKV DLSTYRCLVF KNKAIIRPHA
  1441  TEEIKVLFIP SSPGVFRCTF SVASWPCSTD AETIVQAEAL ASTVTLTAIA ESPVIEVETE
  1501  KKDVLDFGDL TYGGWKALPL KLINRTHATV PIRLIINANA VAWRCFTFSK ESVRAPVEVA
  1561  PCADVVTRLA GPSVVNHMMP ASYDGQDPEF LMIWVLFHSP KKQISSSDIL DSAEEFSAKV
  1621  DIEVDSPNPT PVLRSVSLRA RAGIARIHAP RDLQTMHFLA KVASSRKQHL PLKNAGNIEV
  1681  YLDIKVPEQG SHFSVDPKNL LLKPGEEHEV IVSFTPKDPE ACEERILKIF VQPFGPQYEV
  1741  VLKGEVISSG SKPLSPGPCL DIPSILSNKQ FLAWGGVPLG RTQLQKLALR NNSASTTQHL
  1801  RLLIRGQDQD CFQLQNTFGS EQRLTSNCEI RIHPKEDIFI SVLFAPTRLS CMLARLEIKQ
  1861  LGNRSQPGIK FTIPLSGYGG TSNLILEGVK KLSDSYMVTV NGLVPGKESK IVFSVRNTGS
  1921  RAAFVKAVGF KDSQKKVLLD PKVLRIFPDK FVLKERTQEN VTLIYNPSDR GINNKTATEL
  1981  STVYLFGGDE ISRQQYRRAL LHKPEMIKQI LPEHSVLQNI NFVEAFQDEL LVTEVYDLPQ
  2041  RPNDVQLFYG SMCKIILSVI GEFRDCISSR EFLQPSSKAS LESTSDLGAS GKHGGNVSLD
  2101  VLPVKGPQGS PLLSRAARPP LDQLASEEPW TVLPEHLILV APSPCDMAKT GRFQIVNNSV
  2161  RLLRFELCWP AHCLTVTPQH GCVAPESKLQ ILVSPNSSLS TKQSMFPWSG LIYIHCDDGQ
  2221  KKIVKVQIRE DLTQVELLTR LTSKPFGILS PVSEPSVSHL VKPMTKPPST KVEIRNKSIT
  2281  FPTTEPGETS ESCLELENHG TTDVKWHLSS LAPPYVKGVD ESGDVFRATY AAFRCSPISG
  2341  LLESHGIQKV SITFLPRGRG DYAQFWDVEC HPLKEPHMKH TLRFQLSGQS IEAENEPENA
  2401  CLSTDSLIKI DHLVKPRRQA VSEASARIPE QLDVTARGVY APEDVYRFRP TSVGESRTLK
  2461  VNLRNNSFIT HSLKFLSPRE PFYVKHSKYS LRAQHYINMP VQFKPKSAGK FEALLVIQTD
  2521  EGKSIAIRLI GEALGKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP192 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

thymus: 11 nTPM
bone marrow: 10 nTPM
testis: 8.7 nTPM
ovary: 7.4 nTPM
lymph node: 6.4 nTPM
retina: 6.2 nTPM

Single-cell type

sertoli cells: 291 nCPM
erythrocyte progenitors: 208 nCPM
neutrophil progenitors: 205 nCPM
monocyte progenitors: 196 nCPM
myonuclei: 174 nCPM
cardiomyocytes: 154 nCPM

Immune cell

non-classical monocyte: 1.7 nTPM
naive B-cell: 1.3 nTPM
naive CD8 T-cell: 1 nTPM
gdT-cell: 0.9 nTPM
MAIT T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

cerebellum: 39 nTPM
white matter: 39 nTPM
basal ganglia: 34 nTPM
thalamus: 30 nTPM
cerebral cortex: 30 nTPM
amygdala: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: -0.88
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like fold
Centrosomal protein Spd-2/CEP192
Cep192-like, domain 1
Cep192-like, domain 2
Cep192-like, domain 7
Cep192-like, domain 8
Cep192-like, domain 3
Cep192/Spd-2-like domain
Cep192-like, domain 5
Cep192-like, domain 6
CEP192, Aurora A binding region
CEP192, PLK4 binding region
Cep192 domain 1
Cep192 domain 2
Cep192 domain 7
Cep192 domain 8
Cep192 domain 3
Cep192 domain 4
Cep192 domain 5
Cep192 domain 6
CEP192 Aurora A binding region
CEP192, PLK4 binding region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP192 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP192 as an antibody target. Whether an autoantibody or antibody against CEP192 could matter depends on whether native CEP192 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP192 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP192 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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