Seroatlas · Human Serome Atlas

FRY

Protein furry homolog

Also known as: 13CDNA73, bA37E23.1, C13orf14, CG003, FRY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TBA9
Gene: FRY
Ensembl: ENSG00000073910
Chromosome: 13
Canonical length: 3013 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3013 residues, UniProt reviewed canonical sequence.

>Q5TBA9|FRY
     1  MASQQDSGFF EISIKYLLKS WSNTSPVGNG YIKPPVPPAS GTHREKGPPT MLPINVDPDS
    61  KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC
   121  LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI
   181  EVLKQIPLHP VIDSLIHDVI NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF
   241  PAVKKKFMAE LKELRHKEQN PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY
   301  FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA
   361  LYPLVTCLLC VSQKQLFLNR WHIFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC
   421  ESNTATQSRL ITIITTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC
   481  VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK
   541  TLTEEEAKMI GMSLYYSQVR KAVDNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP
   601  KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE
   661  DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGKVYEQA NKIRNSELIA
   721  NGSSHRIQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FIALGQPEDD
   781  DRPMIDVMDQ LSSSILESFI HVAVSDSATL PLTHNVDLQW LVEWNAVLVN SHYDVKSPSH
   841  VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPINAK
   901  KTSTAGSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG
   961  TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK
  1021  KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN
  1081  DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP
  1141  LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ
  1201  LGCEVVVLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGSRN YPFDIVTLLN
  1261  LVLFKASDTN REIYEISMQL MQILEAKLFV YSKKVAEQRP GSILYGTHGP LPPLYSVSLA
  1321  LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS
  1381  PSSPEDEVKD REGDVTASHG LRGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGPEMENAWN
  1441  ALANNEKWSN NLRITLQFLI SLCGVSSDTV LLPYIKKVAI YLCRNNTIQT MEELLFELQQ
  1501  TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQENFPDAE ENKILKESDE
  1561  RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL TITETKQPQP LPMPCTGGCW
  1621  APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP
  1681  EVFEHSKKLL LHLLIALSCN SNFHSIASVL LQTREMGEAK TLTVQPAYQP EYLYTGGFDF
  1741  LREDQSSPVP DSGLSSSSTS SSISLGGSSG NLPQMTQEVE DVDTAAETDE KANKLIEFLT
  1801  TRAFGPLWCH EDITPKNQNS KSAEQLTNFL RHVVSVFKDS KSGFHLEHQL SEVALQTALA
  1861  SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD
  1921  NLSDCLKNSD LLTVLSRSSS PDLSSSSKLT ASRKSTGQLN MNPGTTSGNT ATAERSRHQR
  1981  SFSVPKKFGV IDRSSDPPRS ATLDRIQACT QQGLSSKTRS SSSLKDSLTD PSHINHPTNL
  2041  LATIFWVTVA LMESDFEFEY LMALRLLSRL LAHMPLDKAE NREKLEKLQA QLKWADFSGL
  2101  QQLLLKGFTS LTTTDLTLQL FSLLTPVSKI SMVDASHAIG FPLNVLCLLP QLIQHFENPN
  2161  QFCKDIAERI AQVCLEEKNP KLSNLAHVMT LYKTHSYTRD CATWVNVVCR YLHEAYADIT
  2221  LNMVTYLAEL LEKGLPSVQQ PLLQVIYSLL SYMDLSVVPV KQFNVEVLKT IEKYVQSVHW
  2281  REALNILKLV VSRSASLVLP SYQHSDLSKI EIHRVWTSAS KELPGKTLDF HFDISETPII
  2341  GRRYDELQNS SGRDGKPRAM AVTRSTSSTS SGSNSNVLVP VSWKRPQYSQ KRTKEKLVHV
  2401  LSLCGQEVGL SKNPSVIFSS CGDLDLLEHQ TSLVSSEDGA REQENMDDTN SEQQFRVFRD
  2461  FDFLDVELED GEGESMDNFN WGVRRRSLDS LDKCDMQILE ERQLSGSTPS LNKMHHEDSD
  2521  ESSEEEDLTA SQILEHSDLI MTLSPSEETN PMELLTTACD STPAEPHSFN TRMSSFDASL
  2581  PDMNNLQISE GSKAEAVREE EDTTVHEDDL SSSINELPAA FECSDSFSLD MTEGEEKGNR
  2641  ALDQFTLASF GEGDRGVSPP PSPFFSAILA AFQPAACDDA EEAWRSHINQ LMCDSDGSCA
  2701  VYTFHVFSSL FKNIQKRFCF LTCDAASYLG DNLRGIGSKF VSSSQMLTSC SECPTLFVDA
  2761  ETLLSCGLLD KLKFSVLELQ EYLDTYNNRK EATLSWLANC KATFAGGSRD GVITCQPGDS
  2821  EEKQLELCQR LYKLHFQLLL LFQSYCKLIG QVHEVSSMPE LLNMSRELSD LKKHLKEASA
  2881  VIAADPLYSD GAWSEPTFTS TEAAIQSMLE CLKNNELGKA LRQIRECRSL WPNDIFGSSS
  2941  DDEVQTLLNI YFRHQTLGQT GTYALVGSNQ SLTEICTKLM ELNMEIRDMI RRAQSYRVLT
  3001  TFLPDSSVSG TSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 24 nTPM
tongue: 18 nTPM
blood vessel: 18 nTPM
cerebellum: 13 nTPM
skeletal muscle: 13 nTPM
retina: 10 nTPM

Single-cell type

podocytes: 1,514 nCPM
neutrophils: 1,014 nCPM
cardiomyocytes: 901 nCPM
vascular smooth muscle cells: 800 nCPM
neutrophil progenitors: 741 nCPM
cone photoreceptor cells: 658 nCPM

Immune cell

eosinophil: 12 nTPM
neutrophil: 8.4 nTPM
basophil: 7.7 nTPM
non-classical monocyte: 1.2 nTPM
classical monocyte: 1.1 nTPM
myeloid DC: 0.8 nTPM

Brain region

cerebellum: 66 nTPM
cerebral cortex: 49 nTPM
basal ganglia: 46 nTPM
pons: 44 nTPM
hypothalamus: 43 nTPM
hippocampal formation: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 4.19
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRY as an antibody target. Whether an autoantibody or antibody against FRY could matter depends on whether native FRY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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