FBXL7

Protein identityUniProt · HPA

UniProt accession

Q9UJT9

Gene

FBXL7

Ensembl

ENSG00000183580

Chromosome

5

Canonical length

491 aa

Protein class

Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q9UJT9|FBXL7
     1  MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT LSTPSPALIC
    61  PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH
   121  SMVQIFSFLP TNQLCRCARV CRRWYNLAWD PRLWRTIRLT GETINVDRAL KVLTRRLCQD
   181  TPNVCLMLET VTVSGCRRLT DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL
   241  EHLDVSGCSK VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
   301  THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES RLRYLSIAHC
   361  GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN CTKLKSLDIG KCPLVSDTGL
   421  ECLALNCFNL KRLSLKSCES ITGQGLQIVA ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR
   481  CVIEHTNPAF F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.31

gnomAD missense Z

2.13

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell division
• G2/M transition of mitotic cell cycle
• mitotic cell cycle
• protein polyubiquitination
• protein ubiquitination
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
• ubiquitin-dependent protein catabolic process

Cellular components

• centrosome
• cytosol
• SCF ubiquitin ligase complex
• ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• Leucine-rich repeat, cysteine-containing subtype
• Leucine-rich repeat domain superfamily
• F-box-like domain superfamily
• F-box/LRR-repeat protein 15-like, leucin rich repeat domain
• F-box-like
• F-box/LRR-repeat protein 15, leucine rich repeat domain

KeywordsUniProt

• Cell cycle
• Cell division
• Cytoplasm
• Cytoskeleton
• Leucine-rich repeat
• Mitosis
• Repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AURKA
• BIRC5