Seroatlas · Human Serome Atlas

BIRC5

Baculoviral IAP repeat-containing protein 5

Also known as: API4, BIRC5_HUMAN, EPR-1, survivin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15392
Gene
BIRC5
Ensembl
ENSG00000089685
Chromosome
17
Canonical length
142 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Cytokinetic bridge
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>O15392|BIRC5
     1  MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC
    61  FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK
   121  KKEFEETAKK VRRAIEQLAA MD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIRC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 38 nTPM
  • bone marrow: 36 nTPM
  • testis: 19 nTPM
  • tonsil: 15 nTPM
  • lymph node: 15 nTPM
  • esophagus: 13 nTPM

Single-cell type

  • late primary spermatocytes: 284 nCPM
  • extravillous trophoblasts: 178 nCPM
  • esophageal basal cells: 169 nCPM
  • erythrocyte progenitors: 155 nCPM
  • migrating cytotrophoblasts: 141 nCPM
  • monocyte progenitors: 135 nCPM

Immune cell

  • T-reg: 14 nTPM
  • memory CD4 T-cell: 4.1 nTPM
  • total PBMC: 3.1 nTPM
  • memory CD8 T-cell: 2.8 nTPM
  • memory B-cell: 2.4 nTPM
  • NK-cell: 2.4 nTPM

Brain region

  • thalamus: 2 nTPM
  • white matter: 1.4 nTPM
  • cerebral cortex: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM
  • pons: 1.1 nTPM
  • basal ganglia: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BIRC5.

Disease | ImmuneIEDB

Conditions an epitope on BIRC5 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against BIRC5 are reported. Each links to that disease's full target list.

Showing 1 of 2 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for BIRC5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

24 publications

Show 19 more

Reference: B cellIEDB

2 publications

Reference: T cellIEDB

17 publications

Show 12 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0.06
gnomAD missense Z
0.47
DepMap mean gene effect
-1.81
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIRC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIRC5 as an antibody target. Whether an autoantibody or antibody against BIRC5 could matter depends on whether native BIRC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIRC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIRC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BIRC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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