Seroatlas · Human Serome Atlas

TPX2

Targeting protein for Xklp2

Also known as: C20orf1, C20orf2, DIL-2, FLS353, HCA519, p100, TPX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULW0
Gene
TPX2
Ensembl
ENSG00000088325
Chromosome
20
Canonical length
747 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytokinetic bridge,Mitotic spindle

OverviewNCBI Gene

Enables importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; nucleoplasm; and spindle. Is active in spindle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q9ULW0|TPX2
     1  MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG TGGLFQGKTP
    61  LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC SSLEVEAAIS RKTPAQPQRR
   121  SLRLSAQKDL EQKEKHHVKM KAKRCATPVI IDEILPSKKM KVSNNKKKPE EEGSAHQDTA
   181  EKNASSPEKA KGRHTVPCMP PAKQKFLKST EEQELEKSMK MQQEVVEMRK KNEEFKKLAL
   241  AGIGQPVKKS VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG
   301  CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD INLLPSKSSV
   361  TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY KFKARELDPR ILEGGPILPK
   421  KPPVKPPTEP IGFDLEIEKR IQERESKKKT EDEHFEFHSR PCPTKILEDV VGVPEKKVLP
   481  ITVPKSPAFA LKNRIRMPTK EDEEEDEPVV IKAQPVPHYG VPFKPQIPEA RTVEICPFSF
   541  DSRDKERQLQ KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR
   601  GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG LSGSLVQEPF
   661  QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK KEELARLRRE LVHKANPIRK
   721  YQGLEIKSSD QPLTVPVSPK FSTRFHC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 66 nTPM
  • bone marrow: 45 nTPM
  • tonsil: 30 nTPM
  • testis: 29 nTPM
  • lymph node: 25 nTPM
  • rectum: 13 nTPM

Single-cell type

  • monocyte progenitors: 274 nCPM
  • erythrocyte progenitors: 227 nCPM
  • megakaryocyte progenitors: 158 nCPM
  • early primary spermatocytes: 121 nCPM
  • neutrophil progenitors: 112 nCPM
  • extravillous trophoblasts: 87 nCPM

Immune cell

  • T-reg: 8.1 nTPM
  • basophil: 5 nTPM
  • NK-cell: 3.6 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • plasmacytoid DC: 1 nTPM

Brain region

  • thalamus: 2.9 nTPM
  • cerebral cortex: 2.4 nTPM
  • pons: 2.3 nTPM
  • basal ganglia: 2 nTPM
  • white matter: 2 nTPM
  • cerebellum: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
0.49
DepMap mean gene effect
-1.31
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TPX2
  • Aurora-A binding
  • TPX2, C-terminal
  • TPX2 central domain
  • Targeting protein for Xklp2 (TPX2) domain
  • Aurora-A binding
  • Cell cycle regulated microtubule associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPX2 as an antibody target. Whether an autoantibody or antibody against TPX2 could matter depends on whether native TPX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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