Seroatlas · Human Serome Atlas

SIRT2

NAD-dependent protein deacetylase sirtuin-2

Also known as: SIR2_HUMAN, SIR2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXJ6
Gene
SIRT2
Ensembl
ENSG00000068903
Chromosome
19
Canonical length
389 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Plasma membrane,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q8IXJ6|SIRT2
     1  MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS LGSQKERLLD
    61  ELTLEGVARY MQSERCRRVI CLVGAGISTS AGIPDFRSPS TGLYDNLEKY HLPYPEAIFE
   121  ISYFKKHPEP FFALAKELYP GQFKPTICHY FMRLLKDKGL LLRCYTQNID TLERIAGLEQ
   181  EDLVEAHGTF YTSHCVSASC RHEYPLSWMK EKIFSEVTPK CEDCQSLVKP DIVFFGESLP
   241  ARFFSCMQSD FLKVDLLLVM GTSLQVQPFA SLISKAPLST PRLLINKEKA GQSDPFLGMI
   301  MGLGGGMDFD SKKAYRDVAW LGECDQGCLA LAELLGWKKE LEDLVRREHA SIDAQSGAGV
   361  PNPSTSASPK KSPPPAKDEA RTTEREKPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
493 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 493 nTPM
  • skeletal muscle: 307 nTPM
  • midbrain: 248 nTPM
  • tongue: 204 nTPM
  • hippocampal formation: 193 nTPM
  • amygdala: 158 nTPM

Single-cell type

  • oligodendrocytes: 303 nCPM
  • oligodendrocyte progenitor cells: 133 nCPM
  • choroid plexus epithelial cells: 53 nCPM
  • astrocytes: 46 nCPM
  • bergmann glia: 42 nCPM
  • brain excitatory neurons: 40 nCPM

Immune cell

  • intermediate monocyte: 68 nTPM
  • eosinophil: 59 nTPM
  • non-classical monocyte: 56 nTPM
  • classical monocyte: 52 nTPM
  • basophil: 49 nTPM
  • total PBMC: 49 nTPM

Brain region

  • white matter: 217 nTPM
  • medulla oblongata: 180 nTPM
  • cerebellum: 159 nTPM
  • basal ganglia: 148 nTPM
  • midbrain: 135 nTPM
  • pons: 134 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIRT2.

Disease | ImmuneIEDB

Conditions an epitope on SIRT2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRT2 as an antibody target. Whether an autoantibody or antibody against SIRT2 could matter depends on whether native SIRT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIRT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIRT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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