Seroatlas · Human Serome Atlas

TACC1

Transforming acidic coiled-coil-containing protein 1

Also known as: TACC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75410
Gene: TACC1
Ensembl: ENSG00000147526
Chromosome: 8
Canonical length: 805 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>O75410|TACC1
     1  MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN
    61  FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN
   121  EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG
   181  KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK
   241  KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
   301  DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK
   361  SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD
   421  NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITSGCKVK KHETQSLALD
   481  ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP
   541  VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
   601  SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA QMIEDEQRTS
   661  MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE ALKKCAQDYL
   721  ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ MKVESLERAL
   781  QQKNQEIEEL TKICDELIAK LGKTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 140 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 140 nTPM
blood vessel: 84 nTPM
smooth muscle: 78 nTPM
endometrium: 72 nTPM
colon: 70 nTPM
cervix: 65 nTPM

Single-cell type

pituicytes/fscs: 1,100 nCPM
pericytes: 1,026 nCPM
vascular endothelial cells: 945 nCPM
vascular smooth muscle cells: 929 nCPM
distal convoluted tubule cells: 749 nCPM
schwann cells: 538 nCPM

Immune cell

plasmacytoid DC: 33 nTPM
neutrophil: 31 nTPM
eosinophil: 15 nTPM
non-classical monocyte: 14 nTPM
basophil: 13 nTPM
classical monocyte: 12 nTPM

Brain region

white matter: 165 nTPM
thalamus: 156 nTPM
basal ganglia: 150 nTPM
cerebral cortex: 147 nTPM
midbrain: 143 nTPM
amygdala: 142 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TACC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TACC1 as an antibody target. Whether an autoantibody or antibody against TACC1 could matter depends on whether native TACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TACC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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