Seroatlas · Human Serome Atlas

GADD45A

Growth arrest and DNA damage-inducible protein GADD45 alpha

Also known as: DDIT1, GA45A_HUMAN, GADD45

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24522
Gene
GADD45A
Ensembl
ENSG00000116717
Chromosome
1
Canonical length
165 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P24522|GADD45A
     1  MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA
    61  ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP
   121  DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GADD45A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
255 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 255 nTPM
  • blood vessel: 232 nTPM
  • liver: 154 nTPM
  • kidney: 153 nTPM
  • adipose tissue: 132 nTPM
  • bone marrow: 129 nTPM

Single-cell type

  • epididymal basal cells: 2,900 nCPM
  • endometrial glandular cells: 1,252 nCPM
  • epididymal clear cells: 996 nCPM
  • endometrial secretory cells: 966 nCPM
  • epididymal efferent duct absorptive cells: 958 nCPM
  • urothelial cells: 878 nCPM

Immune cell

  • eosinophil: 49 nTPM
  • basophil: 24 nTPM
  • T-reg: 19 nTPM
  • total PBMC: 8.7 nTPM
  • neutrophil: 8.2 nTPM
  • NK-cell: 6.5 nTPM

Brain region

  • medulla oblongata: 49 nTPM
  • white matter: 34 nTPM
  • midbrain: 33 nTPM
  • cerebral cortex: 31 nTPM
  • thalamus: 29 nTPM
  • basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0.04
gnomAD missense Z
1.41
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GADD45A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GADD45A as an antibody target. Whether an autoantibody or antibody against GADD45A could matter depends on whether native GADD45A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GADD45A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GADD45A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GADD45A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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