Seroatlas · Human Serome Atlas

GPR143

G-protein coupled receptor 143

Also known as: GP143_HUMAN, OA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51810
Gene
GPR143
Ensembl
ENSG00000101850
Chromosome
X
Canonical length
404 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies,Golgi apparatus,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>P51810|GPR143
     1  MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR LALGLLQLLP GRRPAGPGSP
    61  ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD SVSDMNHTEI WPAAFCVGSA
   121  MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM AWGLATLLCV EGAAMLYYPS
   181  VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV ASLLKGRQGI YTENERRMGA
   241  VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS LKPVRTAAKT TWFIMGILNP
   301  AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA HPSPLMPHEN PASGKVSQVG
   361  GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT HGDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR143 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 23 nTPM
  • basal ganglia: 10 nTPM
  • skin: 8.5 nTPM
  • cerebral cortex: 8.4 nTPM
  • midbrain: 7.4 nTPM
  • amygdala: 6.1 nTPM

Single-cell type

  • melanocytes: 322 nCPM
  • retinal pigment epithelial cells: 124 nCPM
  • cytotrophoblasts: 57 nCPM
  • migrating cytotrophoblasts: 45 nCPM
  • choroid plexus epithelial cells: 26 nCPM
  • proximal tubule cells: 23 nCPM

Immune cell

  • basophil: 3.1 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • midbrain: 15 nTPM
  • choroid plexus: 15 nTPM
  • hypothalamus: 13 nTPM
  • basal ganglia: 12 nTPM
  • medulla oblongata: 12 nTPM
  • pons: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR143.

Disease | AllUniProt

Conditions GPR143 is implicated in, by any mechanism.

Disease | GeneticClinVar

115 pathogenic / likely-pathogenic of 485 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ocular albinism, type I
  • Nystagmus 6, congenital, X-linked
  • GPR143-related foveal hypoplasia
  • GPR143-related disorder
  • Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on GPR143 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.93
gnomAD missense Z
0.88
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • G-protein coupled receptor 143
  • Ocular albinism type 1 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR143 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR143 as an antibody target. Whether an autoantibody or antibody against GPR143 could matter depends on whether native GPR143 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR143 is annotated at the cell surface, where native GPR143 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR143 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR143. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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