Seroatlas · Human Serome Atlas

ACKR4

Atypical chemokine receptor 4

Also known as: ACKR4_HUMAN, CCBP2, CCR11, CCRL1, CCX-CKR, PPR1, VSHK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPB9
Gene
ACKR4
Ensembl
ENSG00000129048
Chromosome
3
Canonical length
350 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Vesicles,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9NPB9|ACKR4
     1  MALEQNQSTD YYYEENEMNG TYDYSQYELI CIKEDVREFA KVFLPVFLTI VFVIGLAGNS
    61  MVVAIYAYYK KQRTKTDVYI LNLAVADLLL LFTLPFWAVN AVHGWVLGKI MCKITSALYT
   121  LNFVSGMQFL ACISIDRYVA VTKVPSQSGV GKPCWIICFC VWMAAILLSI PQLVFYTVND
   181  NARCIPIFPR YLGTSMKALI QMLEICIGFV VPFLIMGVCY FITARTLMKM PNIKISRPLK
   241  VLLTVVIVFI VTQLPYNIVK FCRAIDIIYS LITSCNMSKR MDIAIQVTES IALFHSCLNP
   301  ILYVFMGASF KNYVMKVAKK YGSWRRQRQS VEEFPFDSEG PTEPTSTFSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACKR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 15 nTPM
  • small intestine: 12 nTPM
  • blood vessel: 10 nTPM
  • stomach: 9.6 nTPM
  • adipose tissue: 8.8 nTPM
  • skin: 8 nTPM

Single-cell type

  • cardiomyocytes: 85 nCPM
  • adipocytes: 59 nCPM
  • epicardial cells: 46 nCPM
  • fibro-adipogenic progenitors: 32 nCPM
  • myonuclei: 30 nCPM
  • foveolar cells: 20 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 4.3 nTPM
  • amygdala: 3.6 nTPM
  • midbrain: 3.5 nTPM
  • medulla oblongata: 3.2 nTPM
  • cerebellum: 3.1 nTPM
  • cerebral cortex: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACKR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACKR4 as an antibody target. Whether an autoantibody or antibody against ACKR4 could matter depends on whether native ACKR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACKR4 is annotated at the cell surface, where native ACKR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACKR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACKR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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