GPR135
G-protein coupled receptor 135
Also known as: GP135_HUMAN, HUMNPIIY20, PAFR
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZ08
- Gene
- GPR135
- Ensembl
- ENSG00000181619
- Chromosome
- 14
- Canonical length
- 494 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Enables arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
494 residues, UniProt reviewed canonical sequence.
>Q8IZ08|GPR135
1 MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA ALGNLSDASG
61 GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG AAVAAQALVL LLIFLLSSLG
121 NCAVMGVIVK HRQLRTVTNA FILSLSLSDL LTALLCLPAA FLDLFTPPGG SAPAAAAGPW
181 RGFCAASRFF SSCFGIVSTL SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF
241 SLPWELLGAP RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI
301 CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL VLLAAARQAQ
361 TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR NREEGYRTRN VDAFLPSQGP
421 GLQARSRSRL RNRYANRLGA CNRMSSSNPA SGVAGDVAMW ARKNPVVLFC REGPPEPVTA
481 VTKQPKSEAG DTSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR135 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 5.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.7 nTPM
- choroid plexus: 4.4 nTPM
- pituitary gland: 3.2 nTPM
- fallopian tube: 2.9 nTPM
- blood vessel: 2.8 nTPM
- seminal vesicle: 2.5 nTPM
Single-cell type
- proximal tubule cells: 85 nCPM
- ependymal cells: 79 nCPM
- brain excitatory neurons: 59 nCPM
- choroid plexus epithelial cells: 55 nCPM
- lactotrophs: 47 nCPM
- adipocytes: 44 nCPM
Immune cell
- T-reg: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 12 nTPM
- cerebellum: 11 nTPM
- hypothalamus: 8.1 nTPM
- medulla oblongata: 8 nTPM
- midbrain: 7.8 nTPM
- cerebral cortex: 7.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GPR135 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR135 as an antibody target. Whether an autoantibody or antibody against GPR135 could matter depends on whether native GPR135 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR135 is annotated at the cell surface, where native GPR135 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR135 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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