Seroatlas · Human Serome Atlas

GPR62

G-protein coupled receptor 62

Also known as: GPR62_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZJ7
Gene: GPR62
Ensembl: ENSG00000180929
Chromosome: 3
Canonical length: 368 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables arrestin family protein binding activity. Involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of calcium-mediated signaling. Located in endosome and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q9BZJ7|GPR62
     1  MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY LAHLCVVDLL
    61  AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP ACTLGVAALG LARYRLIVHP
   121  LRPGSRPPPV LVLTAVWAAA GLLGALSLLG TPPAPPPAPA RCSVLAGGLG PFRPLWALLA
   181  FALPALLLLG AYGGIFVVAR RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA
   241  LAPALAVGQF AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
   301  LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE LAGGRSPAYQ
   361  GPPESSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 23 nTPM
hippocampal formation: 11 nTPM
midbrain: 11 nTPM
basal ganglia: 8.4 nTPM
hypothalamus: 6.1 nTPM
amygdala: 5.7 nTPM

Single-cell type

oligodendrocytes: 29 nCPM
other brain neurons: 2.8 nCPM
cone photoreceptor cells: 2.1 nCPM
epididymal clear cells: 2 nCPM
retinal horizontal cells: 2 nCPM
retinal bipolar cells: 1.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 67 nTPM
basal ganglia: 41 nTPM
medulla oblongata: 40 nTPM
cerebral cortex: 37 nTPM
midbrain: 34 nTPM
cerebellum: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.26
gnomAD missense Z: 1.52
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR62 as an antibody target. Whether an autoantibody or antibody against GPR62 could matter depends on whether native GPR62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR62 is annotated at the cell surface, where native GPR62 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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