C5AR1

Protein identityUniProt · HPA

UniProt accession

P21730

Gene

C5AR1

Ensembl

ENSG00000197405

Chromosome

19

Canonical length

350 aa

Protein class

CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Golgi apparatus,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P21730|C5AR1
     1  MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW
    61  VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM
   121  YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE
   181  YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT
   241  LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY
   301  VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5AR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

118 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for C5AR1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.7

gnomAD pLI

0.4

gnomAD missense Z

0.16

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• amyloid-beta clearance
• astrocyte activation
• cellular defense response
• chemotaxis
• cognition
• complement component C5a signaling pathway
• complement receptor mediated signaling pathway
• defense response to Gram-positive bacterium
• immune response
• inflammatory response
• microglial cell activation
• mRNA transcription by RNA polymerase II
• neutrophil chemotaxis
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of angiogenesis
• positive regulation of cytosolic calcium ion concentration
• positive regulation of epithelial cell proliferation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of macrophage chemotaxis
• positive regulation of neutrophil chemotaxis
• positive regulation of vascular endothelial growth factor production
• response to peptidoglycan
• sensory perception of chemical stimulus
• signal transduction
• presynapse organization

Molecular functions

• complement component C5a receptor activity
• G protein-coupled receptor activity

Cellular components

• apical part of cell
• basolateral plasma membrane
• plasma membrane
• secretory granule membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Formyl peptide receptor-related
• Anaphylatoxin chemotactic receptor, C3a/C5a1/C5a2
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)

KeywordsUniProt

• Cell membrane
• Chemotaxis
• Cytoplasmic vesicle
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Sulfation
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of C5AR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARRB1
• ARRB2